9SMO
Crystal Structure of human exonuclease 1 (Exo1) with DNA and compound ART5537
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Exonuclease 1 | polymer | 358 | 40354.8 | 1 | UniProt (Q9UQ84) Pfam (PF00752) Pfam (PF00867) | Homo sapiens (human) | hExo1,Exonuclease I,hExoI |
| 2 | B (C) | DNA (5'-D(*CP*(GS)P*CP*TP*AP*GP*TP*CP*GP*TP*CP*AP*(TS))-3') | polymer | 13 | 3974.7 | 1 | synthetic construct | ||
| 3 | C (B) | DNA (5'-D(P*AP*(SC)P*GP*AP*CP*TP*AP*GP*CP*(GS))-3') | polymer | 10 | 3086.2 | 1 | synthetic construct | ||
| 4 | D, E (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | F (A) | 1-(4-chloranyl-2,7-naphthyridin-1-yl)-5-oxidanyl-3-[(1~{S})-1-phenylethyl]-2~{H}-pyrido[2,1-f][1,2,4]triazine-4,6-dione | non-polymer | 447.9 | 1 | Chemie (A1JO0) | |||
| 6 | G, H (A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 7 | I, J (A, B) | water | water | 18.0 | 49 | Chemie (HOH) |
Sequence modifications
A: 1 - 352 (UniProt: Q9UQ84)
| PDB | External Database | Details |
|---|---|---|
| Glu 353 | - | expression tag |
| Asn 354 | - | expression tag |
| Leu 355 | - | expression tag |
| Tyr 356 | - | expression tag |
| Phe 357 | - | expression tag |
| Gln 358 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 47415.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 542.5 | |
| All* | Total formula weight | 47958.1 |
