9SLD
GABA-A a4b3d receptor in complex with DS2-Me, GABA, Nb24 and Mb30
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Gamma-aminobutyric acid receptor subunit alpha-4 | polymer | 364 | 41783.3 | 2 | UniProt (P48169) | Homo sapiens (human) | GABA(A) receptor subunit alpha-4,GABAAR subunit alpha-4 |
| 2 | B, D (B, D) | Gamma-aminobutyric acid receptor subunit beta-3,Soluble cytochrome b562 | polymer | 451 | 51615.1 | 2 | UniProt (P28472) UniProt (P0ABE7) | Homo sapiens (human) | GABA(A) receptor subunit beta-3,GABAAR subunit beta-3,Cytochrome b-562 |
| 3 | E (E) | Gamma-aminobutyric acid receptor subunit delta | polymer | 430 | 48234.0 | 1 | UniProt (O14764) | Homo sapiens (human) | GABA(A) receptor subunit delta,GABAAR subunit delta |
| 4 | F, H (F, H) | Megabody Mb30 | polymer | 138 | 15386.9 | 2 | Lama glama | ||
| 5 | G, I (G, I) | Nanobody Nb24 | polymer | 133 | 14689.1 | 2 | Lama glama | ||
| 6 | J (P) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 7 | K (Q) | beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G44266EX) | |||
| 8 | L, M, O, P, T... (A, B, D, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) PubChem (24139) | |||
| 9 | N, S (B, D) | GAMMA-AMINO-BUTANOIC ACID | non-polymer | 103.1 | 2 | Chemie (ABU) PubChem (119) | |||
| 10 | Q, R, U, X (B, D, E) | DECANE | non-polymer | 142.3 | 4 | Chemie (D10) PubChem (15600) | |||
| 11 | V (E) | 4-chloranyl-~{N}-(6-methyl-2-thiophen-2-yl-imidazo[1,2-a]pyridin-3-yl)benzamide | non-polymer | 367.9 | 1 | Chemie (A1JOJ) |
Sequence modifications
A, C: 11 - 310 (UniProt: P48169)
A, C: 390 - 427 (UniProt: P48169)
B, D: 1 - 307 (UniProt: P28472)
B, D: 307 - 311 (UniProt: P0ABE7)
E: -83 - -55 (PDB: 9SLD)
E: -54 - -17 (PDB: 9SLD)
E: 0 - 312 (UniProt: O14764)
E: 392 - 418 (UniProt: O14764)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Asn 2 | - | expression tag |
| Ser 3 | - | expression tag |
| Lys 4 | - | expression tag |
| Asp 5 | - | expression tag |
| Glu 6 | - | expression tag |
| Lys 7 | - | expression tag |
| Leu 8 | - | expression tag |
| Cys 9 | - | expression tag |
| Pro 10 | - | expression tag |
| Thr 120 | Met 155 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 311 | - | linker |
| Gln 312 | - | linker |
| Pro 313 | - | linker |
| Ala 314 | - | linker |
| Arg 315 | - | linker |
| Ala 316 | - | linker |
| Ala 317 | - | linker |
| Gly 428 | - | expression tag |
| Thr 429 | - | expression tag |
| Lys 430 | - | expression tag |
| His 431 | - | expression tag |
| His 432 | - | expression tag |
| His 433 | - | expression tag |
| His 434 | - | expression tag |
| His 435 | - | expression tag |
| His 436 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 307 | - | linker |
| Gln 307 | - | linker |
| Pro 307 | - | linker |
| Ala 307 | - | linker |
| Gly 307 | - | linker |
| Thr 307 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Trp 307 | Met 29 | conflict |
| Ile 311 | His 124 | conflict |
| Leu 311 | Arg 128 | conflict |
| Thr 417 | - | expression tag |
| Gly 418 | - | expression tag |
| Arg 419 | - | expression tag |
| Ala 420 | - | expression tag |
| Ala 421 | - | expression tag |
| Ala 422 | - | expression tag |
| Ile 423 | - | expression tag |
| Asp 424 | - | expression tag |
| Arg 425 | - | expression tag |
| Trp 426 | - | expression tag |
| Ser 427 | - | expression tag |
| Arg 428 | - | expression tag |
| Ile 429 | - | expression tag |
| Val 430 | - | expression tag |
| Phe 431 | - | expression tag |
| Pro 432 | - | expression tag |
| Phe 433 | - | expression tag |
| Thr 434 | - | expression tag |
| Phe 435 | - | expression tag |
| Ser 436 | - | expression tag |
| Leu 437 | - | expression tag |
| Phe 438 | - | expression tag |
| Asn 439 | - | expression tag |
| Leu 440 | - | expression tag |
| Val 441 | - | expression tag |
| Tyr 442 | - | expression tag |
| Trp 443 | - | expression tag |
| Leu 444 | - | expression tag |
| Tyr 445 | - | expression tag |
| Tyr 446 | - | expression tag |
| Val 447 | - | expression tag |
| Asn 448 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp -16 | - | linker |
| Tyr -15 | - | linker |
| Asp -14 | - | linker |
| Ile -13 | - | linker |
| Pro -12 | - | linker |
| Thr -11 | - | linker |
| Thr -10 | - | linker |
| Glu -9 | - | linker |
| Asn -8 | - | linker |
| Leu -7 | - | linker |
| Tyr -6 | - | linker |
| Phe -5 | - | linker |
| Gln -4 | - | linker |
| Gly -3 | - | linker |
| Thr -2 | - | linker |
| Gly -1 | - | linker |
E: 0 - 312 (UniProt: O14764)
E: 392 - 418 (UniProt: O14764)
| PDB | External Database | Details |
|---|---|---|
| Ser 313 | - | linker |
| Gln 314 | - | linker |
| Pro 315 | - | linker |
| Ala 316 | - | linker |
| Arg 317 | - | linker |
| Ala 318 | - | linker |
| Ala 319 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 295182.9 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1173.1 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 2470.5 | |
| All* | Total formula weight | 298826.4 |
