9SFX
Secukinumab Fv in complex with human IL-17A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Secukinumab Fv light-chain | polymer | 116 | 12688.0 | 1 | Homo sapiens | ||
| 2 | B (B) | Secukinumab Fv heavy-chain | polymer | 133 | 15297.0 | 1 | Homo sapiens | ||
| 3 | C (C) | Interleukin-17A | polymer | 138 | 15712.8 | 1 | UniProt (Q16552) Pfam (PF06083) | Homo sapiens (human) | IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8 |
| 4 | D (H) | Heavy-chain of anti-IL-17A antibody XAB5 Fv (crystallization aid) | polymer | 122 | 13723.2 | 1 | Homo sapiens | ||
| 5 | E (L) | Light-chain of anti-IL-17A antibody XAB5 (crystallization aid) | polymer | 115 | 12639.0 | 1 | Homo sapiens | ||
| 6 | F, G, H, I (B, C) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 7 | J, K, L, M, N (A, B, C, H, L) | water | water | 18.0 | 35 | Chemie (HOH) |
Sequence modifications
C: 20 - 155 (UniProt: Q16552)
| PDB | External Database | Details |
|---|---|---|
| Gly 18 | - | expression tag |
| Pro 19 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 70060.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 368.4 | |
| All* | Total formula weight | 70428.5 |
