9S9T
Structure of human PKCBeta Kinase domain with Ruboxistaurin, D427N mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform Beta-II of Protein kinase C beta type | polymer | 353 | 40751.3 | 1 | UniProt (P05771) Pfam (PF00069) Pfam (PF00433) | Homo sapiens (human) | PKC-B,PKC-beta |
| 2 | B (A) | (9R)-9-[(DIMETHYLAMINO)METHYL]-6,7,10,11-TETRAHYDRO-9H,18H-5,21:12,17-DIMETHENODIBENZO[E,K]PYRROLO[3,4-H][1,4,13]OXADIA ZACYCLOHEXADECINE-18,20-DIONE | non-polymer | 468.5 | 1 | Chemie (LY4) |
Sequence modifications
A: 322 - 673 (UniProt: P05771)
| PDB | External Database | Details |
|---|---|---|
| Gly 321 | - | expression tag |
| Asn 427 | Asp 427 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40751.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 468.5 | |
| All* | Total formula weight | 41219.9 |
