9RXO

Structure of the PDZ2 domain from human PDZK1 (NHERF3) with the C-terminal residues (KSTQF) of human URAT1 transporter (SLC22A12)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Na(+)/H(+) exchange regulatory cofactor NHE-RF3,Solute carrier family 22 member 12	polymer	91	9990.4	2	UniProt (Q5T2W1) UniProt (Q96S37) Pfam (PF00595)	Homo sapiens (human)	NHERF-3,CFTR-associated protein of 70 kDa,Na(+)/H(+) exchanger regulatory factor 3,Na/Pi cotransporter C-terminal-associated protein 1,NaPi-Cap1,PDZ domain-containing protein 1,Sodium-hydrogen exchanger regulatory factor 3,Organic anion transporter 4-like protein,Renal-specific transporter,RST,Urate anion exchanger 1,URAT1,Urate:anion antiporter SLC22A12
2	C (A)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
3	D, E (A, B)	water	water		18.0	274	Chemie (HOH)

Sequence modifications

A, B: 131 - 215 (UniProt: Q5T2W1)

PDB	External Database	Details
Gly 130	-	expression tag

A, B: 216 - 220 (UniProt: Q96S37)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	19980.8
Non-Polymers*	Number of molecules	1
	Total formula weight	62.1
All*	Total formula weight	20042.8

*Water molecules are not included.