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9RSS

Cryo-EM structure of the Target of Rapamycin Complex 2 (TORC2) with the Avo1 PH domain

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(B, I)
Target of rapamycin complex subunit LST8polymer30334077.92UniProt (P41318)
Pfam (PF00400)
Saccharomyces cerevisiae (brewer's yeast)TORC subunit LST8,Lethal with SEC13 protein 8
2C, H
(A, F)
Serine/threonine-protein kinase TOR2polymer2474281915.42UniProt (P32600)
Pfam (PF11865)
Pfam (PF02259)
Pfam (PF23593)
Pfam (PF08771)
Pfam (PF00454)
Pfam (PF02260)
Saccharomyces cerevisiae (brewer's yeast)Dominant rapamycin resistance protein 2,Phosphatidylinositol 4-kinase TOR2,PI4-kinase TOR2,PI4K TOR2,PtdIns-4-kinase TOR2,Target of rapamycin kinase 2,Temperature-sensitive CSG2 suppressor protein 14
3D, I
(C, J)
Target of rapamycin complex 2 subunit TSC11polymer1430164580.62UniProt (P40061)
Pfam (PF14664)
Pfam (PF14666)
Pfam (PF14663)
Pfam (PF14668)
Saccharomyces cerevisiae (brewer's yeast)TORC2 subunit TSC11,Adheres voraciously to TOR2 protein 3,Temperature-sensitive CSG2 suppressor protein 11
4E, J
(D, K)
Target of rapamycin complex 2 subunit AVO2polymer42647206.52UniProt (Q04749)
Pfam (PF00023)
Saccharomyces cerevisiae (brewer's yeast)TORC2 subunit AVO2,Adheres voraciously to TOR2 protein 2
5F, K
(E, L)
Target of rapamycin complex 2 subunit BIT61polymer54360908.72UniProt (P47041)
Pfam (PF08539)
Saccharomyces cerevisiae (brewer's yeast)TORC2 subunit BIT61,61 kDa binding partner of TOR2 protein
6G, L
(G, M)
Target of rapamycin complex 2 subunit AVO1polymer1176131565.52UniProt (Q08236)
Pfam (PF16978)
Pfam (PF23164)
Pfam (PF16979)
Saccharomyces cerevisiae (brewer's yeast)TORC2 subunit AVO1,Adheres voraciously to TOR2 protein 1
7M, N
(A, F)
INOSITOL HEXAKISPHOSPHATEnon-polymer660.02Chemie (IHP)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains12
Total formula weight1440509.0
Non-Polymers*Number of molecules2
Total formula weight1320.1
All*Total formula weight1441829.1
*Water molecules are not included.

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PDB entries from 2026-08-26

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