9RSS

Cryo-EM structure of the Target of Rapamycin Complex 2 (TORC2) with the Avo1 PH domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000329	cellular_component	fungal-type vacuole membrane
A	0001558	biological_process	regulation of cell growth
A	0004430	molecular_function	1-phosphatidylinositol 4-kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005774	cellular_component	vacuolar membrane
A	0005886	cellular_component	plasma membrane
A	0006995	biological_process	cellular response to nitrogen starvation
A	0007010	biological_process	cytoskeleton organization
A	0007584	biological_process	response to nutrient
A	0010507	biological_process	negative regulation of autophagy
A	0016242	biological_process	negative regulation of macroautophagy
A	0030950	biological_process	establishment or maintenance of actin cytoskeleton polarity
A	0031929	biological_process	TOR signaling
A	0031931	cellular_component	TORC1 complex
A	0031932	cellular_component	TORC2 complex
A	0035025	biological_process	positive regulation of Rho protein signal transduction
A	0038201	cellular_component	TOR complex
A	0038202	biological_process	TORC1 signaling
A	0038203	biological_process	TORC2 signaling
A	0042254	biological_process	ribosome biogenesis
A	0045807	biological_process	positive regulation of endocytosis
A	0051726	biological_process	regulation of cell cycle
A	0106310	molecular_function	protein serine kinase activity
A	1905356	biological_process	regulation of snRNA pseudouridine synthesis
B	0000139	cellular_component	Golgi membrane
B	0001558	biological_process	regulation of cell growth
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005774	cellular_component	vacuolar membrane
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0007165	biological_process	signal transduction
B	0007584	biological_process	response to nutrient
B	0010008	cellular_component	endosome membrane
B	0030950	biological_process	establishment or maintenance of actin cytoskeleton polarity
B	0031505	biological_process	fungal-type cell wall organization
B	0031929	biological_process	TOR signaling
B	0031930	biological_process	mitochondria-nucleus signaling pathway
B	0031931	cellular_component	TORC1 complex
B	0031932	cellular_component	TORC2 complex
B	0032956	biological_process	regulation of actin cytoskeleton organization
B	0034399	cellular_component	nuclear periphery
B	0043539	molecular_function	protein serine/threonine kinase activator activity
B	0051726	biological_process	regulation of cell cycle
B	0098588	cellular_component	bounding membrane of organelle
C	0001558	biological_process	regulation of cell growth
C	0005515	molecular_function	protein binding
C	0005774	cellular_component	vacuolar membrane
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0030148	biological_process	sphingolipid biosynthetic process
C	0030950	biological_process	establishment or maintenance of actin cytoskeleton polarity
C	0031505	biological_process	fungal-type cell wall organization
C	0031929	biological_process	TOR signaling
C	0031932	cellular_component	TORC2 complex
C	0038203	biological_process	TORC2 signaling
C	0043495	molecular_function	protein-membrane adaptor activity
C	0060090	molecular_function	molecular adaptor activity
C	0072659	biological_process	protein localization to plasma membrane
D	0001558	biological_process	regulation of cell growth
D	0003674	molecular_function	molecular_function
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005774	cellular_component	vacuolar membrane
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0030950	biological_process	establishment or maintenance of actin cytoskeleton polarity
D	0031929	biological_process	TOR signaling
D	0031932	cellular_component	TORC2 complex
E	0001558	biological_process	regulation of cell growth
E	0003674	molecular_function	molecular_function
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005774	cellular_component	vacuolar membrane
E	0005886	cellular_component	plasma membrane
E	0007163	biological_process	establishment or maintenance of cell polarity
E	0019887	molecular_function	protein kinase regulator activity
E	0030950	biological_process	establishment or maintenance of actin cytoskeleton polarity
E	0031505	biological_process	fungal-type cell wall organization
E	0031929	biological_process	TOR signaling
E	0031932	cellular_component	TORC2 complex
E	0038203	biological_process	TORC2 signaling
E	0071944	cellular_component	cell periphery
F	0000329	cellular_component	fungal-type vacuole membrane
F	0001558	biological_process	regulation of cell growth
F	0004430	molecular_function	1-phosphatidylinositol 4-kinase activity
F	0004674	molecular_function	protein serine/threonine kinase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005774	cellular_component	vacuolar membrane
F	0005886	cellular_component	plasma membrane
F	0006995	biological_process	cellular response to nitrogen starvation
F	0007010	biological_process	cytoskeleton organization
F	0007584	biological_process	response to nutrient
F	0010507	biological_process	negative regulation of autophagy
F	0016242	biological_process	negative regulation of macroautophagy
F	0030950	biological_process	establishment or maintenance of actin cytoskeleton polarity
F	0031929	biological_process	TOR signaling
F	0031931	cellular_component	TORC1 complex
F	0031932	cellular_component	TORC2 complex
F	0035025	biological_process	positive regulation of Rho protein signal transduction
F	0038201	cellular_component	TOR complex
F	0038202	biological_process	TORC1 signaling
F	0038203	biological_process	TORC2 signaling
F	0042254	biological_process	ribosome biogenesis
F	0045807	biological_process	positive regulation of endocytosis
F	0051726	biological_process	regulation of cell cycle
F	0106310	molecular_function	protein serine kinase activity
F	1905356	biological_process	regulation of snRNA pseudouridine synthesis
G	0001558	biological_process	regulation of cell growth
G	0005515	molecular_function	protein binding
G	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
G	0005737	cellular_component	cytoplasm
G	0005774	cellular_component	vacuolar membrane
G	0005886	cellular_component	plasma membrane
G	0030950	biological_process	establishment or maintenance of actin cytoskeleton polarity
G	0031929	biological_process	TOR signaling
G	0031932	cellular_component	TORC2 complex
G	0038203	biological_process	TORC2 signaling
G	0060090	molecular_function	molecular adaptor activity
I	0000139	cellular_component	Golgi membrane
I	0001558	biological_process	regulation of cell growth
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005774	cellular_component	vacuolar membrane
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0007165	biological_process	signal transduction
I	0007584	biological_process	response to nutrient
I	0010008	cellular_component	endosome membrane
I	0030950	biological_process	establishment or maintenance of actin cytoskeleton polarity
I	0031505	biological_process	fungal-type cell wall organization
I	0031929	biological_process	TOR signaling
I	0031930	biological_process	mitochondria-nucleus signaling pathway
I	0031931	cellular_component	TORC1 complex
I	0031932	cellular_component	TORC2 complex
I	0032956	biological_process	regulation of actin cytoskeleton organization
I	0034399	cellular_component	nuclear periphery
I	0043539	molecular_function	protein serine/threonine kinase activator activity
I	0051726	biological_process	regulation of cell cycle
I	0098588	cellular_component	bounding membrane of organelle
J	0001558	biological_process	regulation of cell growth
J	0005515	molecular_function	protein binding
J	0005774	cellular_component	vacuolar membrane
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0030148	biological_process	sphingolipid biosynthetic process
J	0030950	biological_process	establishment or maintenance of actin cytoskeleton polarity
J	0031505	biological_process	fungal-type cell wall organization
J	0031929	biological_process	TOR signaling
J	0031932	cellular_component	TORC2 complex
J	0038203	biological_process	TORC2 signaling
J	0043495	molecular_function	protein-membrane adaptor activity
J	0060090	molecular_function	molecular adaptor activity
J	0072659	biological_process	protein localization to plasma membrane
K	0001558	biological_process	regulation of cell growth
K	0003674	molecular_function	molecular_function
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005774	cellular_component	vacuolar membrane
K	0005829	cellular_component	cytosol
K	0005886	cellular_component	plasma membrane
K	0030950	biological_process	establishment or maintenance of actin cytoskeleton polarity
K	0031929	biological_process	TOR signaling
K	0031932	cellular_component	TORC2 complex
L	0001558	biological_process	regulation of cell growth
L	0003674	molecular_function	molecular_function
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005774	cellular_component	vacuolar membrane
L	0005886	cellular_component	plasma membrane
L	0007163	biological_process	establishment or maintenance of cell polarity
L	0019887	molecular_function	protein kinase regulator activity
L	0030950	biological_process	establishment or maintenance of actin cytoskeleton polarity
L	0031505	biological_process	fungal-type cell wall organization
L	0031929	biological_process	TOR signaling
L	0031932	cellular_component	TORC2 complex
L	0038203	biological_process	TORC2 signaling
L	0071944	cellular_component	cell periphery
M	0001558	biological_process	regulation of cell growth
M	0005515	molecular_function	protein binding
M	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
M	0005737	cellular_component	cytoplasm
M	0005774	cellular_component	vacuolar membrane
M	0005886	cellular_component	plasma membrane
M	0030950	biological_process	establishment or maintenance of actin cytoskeleton polarity
M	0031929	biological_process	TOR signaling
M	0031932	cellular_component	TORC2 complex
M	0038203	biological_process	TORC2 signaling
M	0060090	molecular_function	molecular adaptor activity

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAgyDhTIRFWEA

Chain	Residue	Details
B	LEU5-ALA19
B	MET90-VAL104
B	LEU131-LEU145
B	LEU265-LEU279

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	76
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	78
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	78
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	78
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	78
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	78
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	76
Details	Repeat: {"description":"HEAT 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	76
Details	Repeat: {"description":"HEAT 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	68
Details	Repeat: {"description":"HEAT 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	74
Details	Repeat: {"description":"HEAT 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	76
Details	Repeat: {"description":"HEAT 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	76
Details	Repeat: {"description":"HEAT 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	76
Details	Repeat: {"description":"HEAT 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	74
Details	Repeat: {"description":"HEAT 9"}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	74
Details	Repeat: {"description":"HEAT 10"}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	78
Details	Repeat: {"description":"HEAT 11"}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	64
Details	Domain: {"description":"FATC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00534","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU00535","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	12
Details	Region: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	16
Details	Region: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	50
Details	Region: {"description":"Activation loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	58
Details	Repeat: {"description":"ANK 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	58
Details	Repeat: {"description":"ANK 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	60
Details	Repeat: {"description":"ANK 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	58
Details	Repeat: {"description":"ANK 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	2
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---