9RSD
Ternary complex of a charged molecular glue degrader ZZ1-SO2H, BRD4(BD1) neosubstrate, and the CTLH E3 ligase receptor module YPEL5-WDR26
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (7, W) | WD repeat-containing protein 26 | polymer | 645 | 70539.8 | 2 | UniProt (Q9H7D7) | Homo sapiens (human) | CUL4- and DDB1-associated WDR protein 2,Myocardial ischemic preconditioning up-regulated protein 2 |
| 2 | C (Y) | Protein yippee-like 5 | polymer | 121 | 13860.7 | 1 | UniProt (P62699) | Homo sapiens (human) | |
| 3 | D (B) | Bromodomain-containing protein 4 | polymer | 130 | 15226.4 | 1 | UniProt (O60885) | Homo sapiens (human) | Protein HUNK1 |
| 4 | E, F, G (7, W, Y) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 5 | H (Y) | 2-chloranyl-4-[[4-[(9S)-4,5,13-trimethyl-9-[2-[(2-methylpropan-2-yl)oxy]-2-oxidanylidene-ethyl]-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-7-yl]phenyl]carbamoyl]benzenesulfinic acid | non-polymer | 640.2 | 1 | Chemie (A1IL9) | |||
| 6 | I, J (Y, B) | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
B: 44 - 168 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Gly 39 | - | expression tag |
| Gly 40 | - | expression tag |
| Ser 41 | - | expression tag |
| Gly 42 | - | expression tag |
| Ser 43 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 170166.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 836.4 | |
| All* | Total formula weight | 171003.0 |
