9RSD
Ternary complex of a charged molecular glue degrader ZZ1-SO2H, BRD4(BD1) neosubstrate, and the CTLH E3 ligase receptor module YPEL5-WDR26
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| 7 | 0000151 | cellular_component | ubiquitin ligase complex |
| 7 | 0005515 | molecular_function | protein binding |
| 7 | 0005634 | cellular_component | nucleus |
| 7 | 0005654 | cellular_component | nucleoplasm |
| 7 | 0005737 | cellular_component | cytoplasm |
| 7 | 0005739 | cellular_component | mitochondrion |
| 7 | 0005829 | cellular_component | cytosol |
| 7 | 0034657 | cellular_component | GID complex |
| 7 | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| W | 0000151 | cellular_component | ubiquitin ligase complex |
| W | 0005515 | molecular_function | protein binding |
| W | 0005634 | cellular_component | nucleus |
| W | 0005654 | cellular_component | nucleoplasm |
| W | 0005737 | cellular_component | cytoplasm |
| W | 0005739 | cellular_component | mitochondrion |
| W | 0005829 | cellular_component | cytosol |
| W | 0034657 | cellular_component | GID complex |
| W | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| Y | 0000151 | cellular_component | ubiquitin ligase complex |
| Y | 0000922 | cellular_component | spindle pole |
| Y | 0005515 | molecular_function | protein binding |
| Y | 0005576 | cellular_component | extracellular region |
| Y | 0005634 | cellular_component | nucleus |
| Y | 0005813 | cellular_component | centrosome |
| Y | 0008283 | biological_process | cell population proliferation |
| Y | 0030496 | cellular_component | midbody |
| Y | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| Y | 0097431 | cellular_component | mitotic spindle pole |
| Y | 1904724 | cellular_component | tertiary granule lumen |
| Y | 1904813 | cellular_component | ficolin-1-rich granule lumen |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY |
| Chain | Residue | Details |
| B | ALA80-TYR139 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 78 |
| Details | Repeat: {"description":"WD 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 78 |
| Details | Repeat: {"description":"WD 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 80 |
| Details | Repeat: {"description":"WD 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 78 |
| Details | Repeat: {"description":"WD 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 84 |
| Details | Repeat: {"description":"WD 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 32 |
| Details | Domain: {"description":"LisH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00126","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 97 |
| Details | Domain: {"description":"Yippee","evidences":[{"source":"PROSITE-ProRule","id":"PRU01128","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01128","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Site: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
