9RHG
FZD7 in complex with negative allosteric modulator C407
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, A) | Frizzled-7 | polymer | 603 | 67460.9 | 2 | UniProt (O75084) Pfam (PF01392) Pfam (PF01534) | Homo sapiens (human) | Fz-7,hFz7,FzE3 |
| 2 | C, D, F, G (B, A) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 4 | Chemie (Y01) PubChem (16219150) PubChem (22210610) PubChem (65082) PubChem (363416) PubChem (45489984) PubChem (500055) PubChem (60078761) PubChem (57163942) PubChem (73440805) PubChem (89891013) PubChem (13301926) PubChem (13301927) PubChem (99567469) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (11969853) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (137392566) PubChem (137496323) PubChem (124914595) PubChem (124914596) PubChem (131705526) PubChem (155804219) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (169132514) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) | |||
| 3 | E (B) | ethyl 3-[2-[(2-fluorophenyl)amino]-2-oxidanylidene-ethyl]-5-methyl-4-oxidanylidene-thieno[2,3-d]pyrimidine-6-carboxylate | non-polymer | 389.4 | 1 | Chemie (A1JGQ) |
Sequence modifications
B, A: 33 - 574 (UniProt: O75084)
| PDB | External Database | Details |
|---|---|---|
| Met 10 | - | initiating methionine |
| Lys 11 | - | expression tag |
| Thr 12 | - | expression tag |
| Ile 13 | - | expression tag |
| Ile 14 | - | expression tag |
| Ala 15 | - | expression tag |
| Leu 16 | - | expression tag |
| Ser 17 | - | expression tag |
| Tyr 18 | - | expression tag |
| Ile 19 | - | expression tag |
| Phe 20 | - | expression tag |
| Cys 21 | - | expression tag |
| Leu 22 | - | expression tag |
| Val 23 | - | expression tag |
| Phe 24 | - | expression tag |
| Ala 25 | - | expression tag |
| Asp 26 | - | expression tag |
| Tyr 27 | - | expression tag |
| Lys 28 | - | expression tag |
| Asp 29 | - | expression tag |
| Asp 30 | - | expression tag |
| Asp 31 | - | expression tag |
| Asp 32 | - | expression tag |
| Ser 575 | - | expression tag |
| Arg 576 | - | expression tag |
| Leu 577 | - | expression tag |
| Glu 578 | - | expression tag |
| Val 579 | - | expression tag |
| Leu 580 | - | expression tag |
| Phe 581 | - | expression tag |
| Gln 582 | - | expression tag |
| Gly 583 | - | expression tag |
| Pro 584 | - | expression tag |
| Trp 585 | - | expression tag |
| Ser 586 | - | expression tag |
| His 587 | - | expression tag |
| Pro 588 | - | expression tag |
| Gln 589 | - | expression tag |
| Phe 590 | - | expression tag |
| Glu 591 | - | expression tag |
| Lys 592 | - | expression tag |
| Gly 593 | - | expression tag |
| Gly 594 | - | expression tag |
| Gly 595 | - | expression tag |
| Ser 596 | - | expression tag |
| Gly 597 | - | expression tag |
| Gly 598 | - | expression tag |
| Gly 599 | - | expression tag |
| Ser 600 | - | expression tag |
| Gly 601 | - | expression tag |
| Gly 602 | - | expression tag |
| Gly 603 | - | expression tag |
| Ser 604 | - | expression tag |
| Trp 605 | - | expression tag |
| Ser 606 | - | expression tag |
| His 607 | - | expression tag |
| Pro 608 | - | expression tag |
| Gln 609 | - | expression tag |
| Phe 610 | - | expression tag |
| Glu 611 | - | expression tag |
| Lys 612 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 134921.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 2336.3 | |
| All* | Total formula weight | 137258.0 |
