9RHG

FZD7 in complex with negative allosteric modulator C407

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005109	molecular_function	frizzled binding
A	0005515	molecular_function	protein binding
A	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
A	0005886	cellular_component	plasma membrane
A	0006355	biological_process	regulation of DNA-templated transcription
A	0010008	cellular_component	endosome membrane
A	0010812	biological_process	negative regulation of cell-substrate adhesion
A	0016020	cellular_component	membrane
A	0017147	molecular_function	Wnt-protein binding
A	0019827	biological_process	stem cell population maintenance
A	0030165	molecular_function	PDZ domain binding
A	0030182	biological_process	neuron differentiation
A	0035567	biological_process	non-canonical Wnt signaling pathway
A	0042327	biological_process	positive regulation of phosphorylation
A	0042666	biological_process	negative regulation of ectodermal cell fate specification
A	0042813	molecular_function	Wnt receptor activity
A	0043410	biological_process	positive regulation of MAPK cascade
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0046330	biological_process	positive regulation of JNK cascade
A	0055038	cellular_component	recycling endosome membrane
A	0060054	biological_process	positive regulation of epithelial cell proliferation involved in wound healing
A	0060070	biological_process	canonical Wnt signaling pathway
A	0060071	biological_process	Wnt signaling pathway, planar cell polarity pathway
A	0060231	biological_process	mesenchymal to epithelial transition
A	0060828	biological_process	regulation of canonical Wnt signaling pathway
A	0071300	biological_process	cellular response to retinoic acid
A	2000726	biological_process	negative regulation of cardiac muscle cell differentiation
B	0005109	molecular_function	frizzled binding
B	0005515	molecular_function	protein binding
B	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
B	0005886	cellular_component	plasma membrane
B	0006355	biological_process	regulation of DNA-templated transcription
B	0010008	cellular_component	endosome membrane
B	0010812	biological_process	negative regulation of cell-substrate adhesion
B	0016020	cellular_component	membrane
B	0017147	molecular_function	Wnt-protein binding
B	0019827	biological_process	stem cell population maintenance
B	0030165	molecular_function	PDZ domain binding
B	0030182	biological_process	neuron differentiation
B	0035567	biological_process	non-canonical Wnt signaling pathway
B	0042327	biological_process	positive regulation of phosphorylation
B	0042666	biological_process	negative regulation of ectodermal cell fate specification
B	0042813	molecular_function	Wnt receptor activity
B	0043410	biological_process	positive regulation of MAPK cascade
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0046330	biological_process	positive regulation of JNK cascade
B	0055038	cellular_component	recycling endosome membrane
B	0060054	biological_process	positive regulation of epithelial cell proliferation involved in wound healing
B	0060070	biological_process	canonical Wnt signaling pathway
B	0060071	biological_process	Wnt signaling pathway, planar cell polarity pathway
B	0060231	biological_process	mesenchymal to epithelial transition
B	0060828	biological_process	regulation of canonical Wnt signaling pathway
B	0071300	biological_process	cellular response to retinoic acid
B	2000726	biological_process	negative regulation of cardiac muscle cell differentiation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	62
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	168
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	10
Details	Motif: {"description":"Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---