9R8V
Cryo-EM structure of the human pre-Bact-OTS complex (whole map)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Pre-mRNA-processing-splicing factor 8 | polymer | 2769 | 325927.9 | 1 | Homo sapiens | ||
| 2 | B (B) | U5 small nuclear ribonucleoprotein 200 kDa helicase | polymer | 2136 | 244823.4 | 1 | UniProt (O75643) Pfam (PF21188) Pfam (PF18149) Pfam (PF00270) Pfam (PF00271) Pfam (PF23445) Pfam (PF02889) | Homo sapiens (human) | Activating signal cointegrator 1 complex subunit 3-like 1,BRR2 homolog,U5 snRNP-specific 200 kDa protein,U5-200KD |
| 3 | C (2) | U2 snRNA | polymer | 188 | 60186.4 | 1 | GenBank (36516) | Homo sapiens (human) | |
| 4 | D (6) | U6 snRNA | polymer | 106 | 34098.3 | 1 | GenBank (NR_004394.1) | Homo sapiens (human) | |
| 5 | E (7) | Splicing factor 3A subunit 1 | polymer | 793 | 88991.1 | 1 | UniProt (Q15459) Pfam (PF01805) Pfam (PF12230) Pfam (PF00240) | Homo sapiens (human) | SF3a120,Spliceosome-associated protein 114,SAP 114 |
| 6 | F (5) | U5 snRNA | polymer | 117 | 37254.9 | 1 | GenBank (20330981) | Homo sapiens (human) | |
| 7 | G (L) | Cell division cycle 5-like protein | polymer | 802 | 92406.9 | 1 | UniProt (Q99459) Pfam (PF13921) Pfam (PF11831) | Homo sapiens (human) | Cdc5-like protein,Pombe cdc5-related protein |
| 8 | H (C) | 116 kDa U5 small nuclear ribonucleoprotein component | polymer | 972 | 109560.6 | 1 | UniProt (Q15029) Pfam (PF16004) Pfam (PF00009) Pfam (PF03144) Pfam (PF14492) Pfam (PF03764) Pfam (PF00679) | Homo sapiens (human) | Elongation factor Tu GTP-binding domain-containing protein 2,SNU114 homolog,hSNU114,U5 snRNP-specific protein,116 kDa,U5-116 kDa |
| 9 | I (E) | U5 small nuclear ribonucleoprotein 40 kDa protein | polymer | 357 | 39359.5 | 1 | UniProt (Q96DI7) Pfam (PF00400) | Homo sapiens (human) | U5 snRNP 40 kDa protein,U5-40K,38 kDa-splicing factor,Prp8-binding protein,hPRP8BP,U5 snRNP-specific 40 kDa protein,WD repeat-containing protein 57 |
| 10 | J (G) | Pleiotropic regulator 1 | polymer | 514 | 57280.8 | 1 | UniProt (O43660) Pfam (PF00400) | Homo sapiens (human) | |
| 11 | K (I) | Pre-mRNA-splicing factor 38A | polymer | 312 | 37563.9 | 1 | UniProt (Q8NAV1) Pfam (PF03371) Pfam (PF12871) | Homo sapiens (human) | |
| 12 | L (Q) | Protein BUD31 homolog | polymer | 144 | 17032.8 | 1 | UniProt (P41223) Pfam (PF01125) | Homo sapiens (human) | Protein EDG-2,Protein G10 homolog |
| 13 | M (R) | Spliceosome-associated protein CWC15 homolog | polymer | 229 | 26674.4 | 1 | UniProt (Q9P013) Pfam (PF04889) | Homo sapiens (human) | |
| 14 | N (X) | WW domain-binding protein 11 | polymer | 641 | 70098.6 | 1 | UniProt (Q9Y2W2) Pfam (PF09429) | Homo sapiens (human) | WBP-11,Npw38-binding protein,NpwBP,SH3 domain-binding protein SNP70,Splicing factor that interacts with PQBP-1 and PP1 |
| 15 | O (q) | Ubiquitin-like protein 5 | polymer | 73 | 8560.9 | 1 | UniProt (Q9BZL1) Pfam (PF00240) | Homo sapiens (human) | |
| 16 | P (r) | Zinc finger matrin-type protein 2 | polymer | 199 | 23664.0 | 1 | UniProt (Q96NC0) Pfam (PF12171) | Homo sapiens (human) | |
| 17 | Q, TA (22, 52) | Small nuclear ribonucleoprotein Sm D2 | polymer | 118 | 13551.9 | 2 | UniProt (P62316) Pfam (PF01423) | Homo sapiens (human) | Sm-D2,snRNP core protein D2 |
| 18 | R (2B) | U2 small nuclear ribonucleoprotein B'' | polymer | 225 | 25524.4 | 1 | UniProt (P08579) Pfam (PF00076) | Homo sapiens (human) | U2 snRNP B'' |
| 19 | S, WA (2f, 5f) | Small nuclear ribonucleoprotein F | polymer | 86 | 9734.2 | 2 | UniProt (P62306) Pfam (PF01423) | Homo sapiens (human) | snRNP-F,Sm protein F,SmF |
| 20 | RA, T (2b, 5b) | Small nuclear ribonucleoprotein-associated proteins B and B' | polymer | 240 | 24642.1 | 2 | UniProt (P14678) Pfam (PF01423) | Homo sapiens (human) | snRNP-B,Sm protein B/B',Sm-B/B',SmB/B' |
| 21 | U, UA (23, 53) | Small nuclear ribonucleoprotein Sm D3 | polymer | 126 | 13940.3 | 2 | UniProt (P62318) Pfam (PF01423) | Homo sapiens (human) | Sm-D3,snRNP core protein D3 |
| 22 | V, XA (2g, 5g) | Small nuclear ribonucleoprotein G | polymer | 76 | 8508.1 | 2 | UniProt (P62308) Pfam (PF01423) | Homo sapiens (human) | snRNP-G,Sm protein G,Sm-G,SmG |
| 23 | VA, W (2e, 5e) | Small nuclear ribonucleoprotein E | polymer | 92 | 10817.6 | 2 | UniProt (P62304) Pfam (PF01423) | Homo sapiens (human) | snRNP-E,Sm protein E,Sm-E,SmE |
| 24 | SA, X (21, 51) | Small nuclear ribonucleoprotein Sm D1 | polymer | 119 | 13310.7 | 2 | UniProt (P62314) Pfam (PF01423) | Homo sapiens (human) | Sm-D1,Sm-D autoantigen,snRNP core protein D1 |
| 25 | Y (2A) | U2 small nuclear ribonucleoprotein A' | polymer | 255 | 28456.6 | 1 | UniProt (P09661) Pfam (PF14580) | Homo sapiens (human) | U2 snRNP A' |
| 26 | Z (B4) | Splicing factor 3B subunit 4 | polymer | 424 | 44436.6 | 1 | UniProt (Q15427) Pfam (PF00076) | Homo sapiens (human) | Pre-mRNA-splicing factor SF3b 49 kDa subunit,Spliceosome-associated protein 49,SAP 49 |
| 27 | AA (9) | Splicing factor 3A subunit 3 | polymer | 501 | 58934.8 | 1 | UniProt (Q12874) Pfam (PF12108) Pfam (PF16837) Pfam (PF13297) Pfam (PF11931) | Homo sapiens (human) | SF3a60,Spliceosome-associated protein 61,SAP 61 |
| 28 | BA (8) | Splicing factor 3A subunit 2 | polymer | 464 | 49327.4 | 1 | UniProt (Q15428) Pfam (PF12874) Pfam (PF16835) | Homo sapiens (human) | SF3a66,Spliceosome-associated protein 62,SAP 62 |
| 29 | CA (B2) | Splicing factor 3B subunit 2 | polymer | 895 | 100377.8 | 1 | UniProt (Q13435) Pfam (PF02037) Pfam (PF04037) Pfam (PF04046) | Homo sapiens (human) | Pre-mRNA-splicing factor SF3b 145 kDa subunit,SF3b145,Spliceosome-associated protein 145,SAP 145 |
| 30 | DA (B5) | Splicing factor 3B subunit 5 | polymer | 86 | 10149.4 | 1 | UniProt (Q9BWJ5) Pfam (PF07189) | Homo sapiens (human) | SF3b5,Pre-mRNA-splicing factor SF3b 10 kDa subunit |
| 31 | EA (B3) | Splicing factor 3B subunit 3 | polymer | 1217 | 135718.8 | 1 | UniProt (Q15393) Pfam (PF10433) Pfam (PF23726) Pfam (PF03178) | Homo sapiens (human) | Pre-mRNA-splicing factor SF3b 130 kDa subunit,SF3b130,STAF130,Spliceosome-associated protein 130,SAP 130 |
| 32 | FA (B1) | Splicing factor 3B subunit 1 | polymer | 1304 | 146024.9 | 1 | UniProt (O75533) Pfam (PF08920) Pfam (PF22646) | Homo sapiens (human) | Pre-mRNA-splicing factor SF3b 155 kDa subunit,SF3b155,Spliceosome-associated protein 155,SAP 155 |
| 33 | GA (B6) | Splicing factor 3B subunit 6 | polymer | 125 | 14606.9 | 1 | UniProt (Q9Y3B4) Pfam (PF00076) | Homo sapiens (human) | Pre-mRNA branch site protein p14,SF3b 14 kDa subunit,SF3B14a,Spliceosome-associated protein,14-kDa,Splicing factor 3b,subunit 6,14kDa |
| 34 | HA (BL) | Beta-catenin-like protein 1 | polymer | 563 | 65264.3 | 1 | UniProt (Q8WYA6) Pfam (PF08216) | Homo sapiens (human) | Nuclear-associated protein,NAP,Testis development protein NYD-SP19 |
| 35 | IA (SR) | U2 snRNP-associated SURP motif-containing protein | polymer | 1029 | 118503.3 | 1 | UniProt (O15042) Pfam (PF00076) Pfam (PF01805) Pfam (PF04818) Pfam (PF08312) | Homo sapiens (human) | 140 kDa Ser/Arg-rich domain protein,U2-associated protein SR140 |
| 36 | JA (DH) | ATP-dependent RNA helicase DHX15 | polymer | 795 | 91065.8 | 1 | UniProt (O43143) Pfam (PF00270) Pfam (PF00271) Pfam (PF04408) Pfam (PF21010) Pfam (PF07717) | Homo sapiens (human) | ATP-dependent RNA helicase #46,DEAH box protein 15,Splicing factor Prp43,hPrp43 |
| 37 | KA (Z) | pre-mRNA | polymer | 410 | 132594.5 | 1 | Homo sapiens | ||
| 38 | LA, MA (x, y) | Protein Red | polymer | 557 | 65731.5 | 2 | UniProt (Q13123) Pfam (PF07808) Pfam (PF07807) | Homo sapiens (human) | |
| 39 | NA, OA (v, w) | WD40 repeat-containing protein SMU1 | polymer | 513 | 57616.7 | 2 | UniProt (Q2TAY7) Pfam (PF17814) Pfam (PF00400) | Homo sapiens (human) | Smu-1 suppressor of mec-8 and unc-52 protein homolog |
| 40 | PA (P) | Pre-mRNA-splicing factor RBM22 | polymer | 500 | 56285.6 | 1 | Homo sapiens | ||
| 41 | QA (t) | RING-type E3 ubiquitin-protein ligase PPIL2 | polymer | 520 | 58910.4 | 1 | UniProt (Q13356) Pfam (PF00160) | Homo sapiens (human) | CYC4,Cyclophilin-60,Cyclophilin-like protein Cyp-60,Cyp60,hCyP-60,Probable inactive peptidyl-prolyl cis-trans isomerase-like 2,PPIase,Rotamase PPIL2 |
| 42 | YA (62) | U6 snRNA-associated Sm-like protein LSm2 | polymer | 95 | 10847.5 | 1 | UniProt (Q9Y333) Pfam (PF01423) | Homo sapiens (human) | Protein G7b,Small nuclear ribonuclear protein D homolog,snRNP core Sm-like protein Sm-x5 |
| 43 | ZA (63) | U6 snRNA-associated Sm-like protein LSm3 | polymer | 102 | 11859.4 | 1 | UniProt (P62310) Pfam (PF01423) | Homo sapiens (human) | |
| 44 | AB (64) | U6 snRNA-associated Sm-like protein LSm4 | polymer | 139 | 15375.8 | 1 | UniProt (Q9Y4Z0) Pfam (PF01423) | Homo sapiens (human) | Glycine-rich protein,GRP |
| 45 | BB (65) | U6 snRNA-associated Sm-like protein LSm5 | polymer | 91 | 9945.4 | 1 | UniProt (Q9Y4Y9) Pfam (PF01423) | Homo sapiens (human) | |
| 46 | CB (66) | U6 snRNA-associated Sm-like protein LSm6 | polymer | 80 | 9139.6 | 1 | UniProt (P62312) Pfam (PF01423) | Homo sapiens (human) | |
| 47 | DB (67) | U6 snRNA-associated Sm-like protein LSm7 | polymer | 103 | 11617.4 | 1 | UniProt (Q9UK45) Pfam (PF01423) | Homo sapiens (human) | |
| 48 | EB (68) | U6 snRNA-associated Sm-like protein LSm8 | polymer | 96 | 10410.6 | 1 | UniProt (O95777) Pfam (PF01423) | Homo sapiens (human) | |
| 49 | FB (S1) | SNW domain-containing protein 1 | polymer | 536 | 61610.7 | 1 | UniProt (Q13573) Pfam (PF02731) | Homo sapiens (human) | Nuclear protein SkiP,Nuclear receptor coactivator NCoA-62,Ski-interacting protein |
| 50 | GB (A6) | Serine/arginine-rich splicing factor 1 | polymer | 248 | 27798.8 | 1 | UniProt (Q07955) Pfam (PF00076) | Homo sapiens (human) | Alternative-splicing factor 1,ASF-1,Splicing factor,arginine/serine-rich 1,pre-mRNA-splicing factor SF2,P33 subunit |
| 51 | HB (T) | Transcription elongation regulator 1 | polymer | 1098 | 124083.0 | 1 | UniProt (O14776) Pfam (PF01846) Pfam (PF00397) Pfam (PF23517) | Homo sapiens (human) | TATA box-binding protein-associated factor 2S,Transcription factor CA150 |
| 52 | IB (K) | Microfibrillar-associated protein 1 | polymer | 439 | 52050.5 | 1 | UniProt (P55081) Pfam (PF06991) | Homo sapiens (human) | Spliceosome B complex protein MFAP1 |
| 53 | JB (P7) | Pre-mRNA-processing factor 17 | polymer | 579 | 65612.2 | 1 | UniProt (O60508) Pfam (PF00400) | Homo sapiens (human) | Cell division cycle 40 homolog,EH-binding protein 3,Ehb3,PRP17 homolog,hPRP17 |
| 54 | KB (5A) | PHD finger-like domain-containing protein 5A | polymer | 110 | 12427.5 | 1 | UniProt (Q7RTV0) Pfam (PF03660) | Homo sapiens (human) | PHD finger-like domain protein 5A,Splicing factor 3B-associated 14 kDa protein,SF3b14b |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 63 |
| Total formula weight | 3268150.6 | |
| All* | Total formula weight | 3268150.6 |
