9R5Z

Crystal structure of JAK3 with GCL258

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tyrosine-protein kinase JAK3	polymer	294	33417.3	2	UniProt (P52333) Pfam (PF07714)	Homo sapiens (human)	Janus kinase 3,JAK-3,Leukocyte janus kinase,L-JAK
2	C, E (A, B)	3-(3-cyclohexyl-3,8,10-triazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8,11-pentaen-5-yl)benzenesulfonyl fluoride	non-polymer		397.5	2	Chemie (A1JJU)
3	D, F (A, B)	1-phenylurea	non-polymer		136.2	2	Chemie (PHU)
4	G, H (A, B)	water	water		18.0	218	Chemie (HOH)

Sequence modifications

A, B: -9 - 280 (UniProt: P52333)

PDB	External Database	Details
Ser -11	-	expression tag
Met -10	-	expression tag
Ala 128	Asp 949	conflict
Ser 218	Cys 1040	conflict
Ser 225	Cys 1048	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	66834.6
Non-Polymers*	Number of molecules	4
	Total formula weight	1067.2
All*	Total formula weight	67901.8

*Water molecules are not included.