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9R5T

NSP14 IN COMPLEX WITH LIGAND TDI-016037-NX-1

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Guanine-N7 methyltransferase nsp14polymer52859872.52UniProt (P0DTD1)
Pfam (PF06471)
Severe acute respiratory syndrome coronavirusNon-structural protein 14,nsp14,Proofreading exoribonuclease nsp14,ExoN
2BA, C, D, E, R...
(B, A)
ZINC IONnon-polymer65.47Chemie (ZN)
3F, U
(A, B)
S-ADENOSYL-L-HOMOCYSTEINEnon-polymer384.42Chemie (SAH)
4G, Y
(A, B)
~{N}-[(1-cyclopropyl-6-fluoranyl-indazol-7-yl)methyl]-1,5-dimethyl-4-[(7-methyl-2~{H}-indazol-5-yl)sulfonyl]pyrrole-2-carboxamidenon-polymer520.62Chemie (A1JDF)
5AA, H, I, Z
(B, A)
CHLORIDE IONnon-polymer35.54Chemie (CL)
6CA, DA, EA, FA, GA...
(B, A)
1,2-ETHANEDIOLnon-polymer62.113Chemie (EDO)
7IA, Q, V, W, X
(B, A)
IMIDAZOLEnon-polymer69.15Chemie (IMD)
8JA, KA, LA, MA
(B)
ISOPROPYL ALCOHOLnon-polymer60.14Chemie (IPA)
9NA, OA
(B)
SULFATE IONnon-polymer96.12Chemie (SO4)
10PA, QA
(A, B)
waterwater18.0343Chemie (HOH)
Sequence modifications
A, B: 1 - 527 (UniProt: P0DTD1)
PDBExternal DatabaseDetails
Ser 0-expression tag
Ala 90Asp 6015engineered mutation
Ala 92Glu 6017engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight119745.0
Non-Polymers*Number of molecules39
Total formula weight3994.5
All*Total formula weight123739.5
*Water molecules are not included.

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