9R2I
Cryo-EM structure of the complex CDK16:CCNY:14-3-3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 14-3-3 protein eta | polymer | 248 | 28446.9 | 2 | UniProt (Q04917) | Homo sapiens (human) | Protein AS1 |
| 2 | C (C) | Cyclin-dependent kinase 16 | polymer | 395 | 45088.8 | 1 | UniProt (Q00536) | Homo sapiens (human) | Cell division protein kinase 16,PCTAIRE-motif protein kinase 1,Serine/threonine-protein kinase PCTAIRE-1 |
| 3 | D (D) | Cyclin-Y | polymer | 346 | 40004.1 | 1 | UniProt (Q8ND76) | Homo sapiens (human) | Cyc-Y,Cyclin box protein 1,Cyclin fold protein 1,cyclin-X |
| 4 | E (C) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 5 | F (C) | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | non-polymer | 523.2 | 1 | Chemie (AGS) |
Sequence modifications
A, B: 1 - 246 (UniProt: Q04917)
C: 107 - 496 (UniProt: Q00536)
D: 1 - 341 (UniProt: Q8ND76)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| His 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 102 | - | expression tag |
| Pro 103 | - | expression tag |
| Leu 104 | - | expression tag |
| Gly 105 | - | expression tag |
| Ser 106 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Leu -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Arg 98 | Tyr 98 | engineered mutation |
| Ala 99 | Ser 99 | engineered mutation |
| Ala 324 | Ser 324 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 141986.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 547.6 | |
| All* | Total formula weight | 142534.3 |
