9R1T

Structure of the human chimera HCN112 hyperpolarization-activated cyclic nucleotide-gated ion channel in complex with cAMP.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2,HCN112 holo, in complex with cAMP	polymer	658	72852.2	4	UniProt (O60741) UniProt (O88703) Pfam (PF08412) Pfam (PF00520) Pfam (PF00027)	Homo sapiens (human)	Brain cyclic nucleotide-gated channel 1,BCNG-1,Brain cyclic nucleotide-gated channel 2,BCNG-2,Hyperpolarization-activated cation channel 1,HAC-1
2	E, F, G, H (A, B, C, D)	ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE	non-polymer		329.2	4	Chemie (CMP)

Sequence modifications

A, B, C, D: 1 - 401 (UniProt: O60741)
A, B, C, D: 402 - 605 (UniProt: O88703)
A, B, C, D: 906 - 958 (PDB: 9R1T)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	291408.8
Non-Polymers*	Number of molecules	4
	Total formula weight	1316.8
All*	Total formula weight	292725.6

*Water molecules are not included.