9R1T

Structure of the human chimera HCN112 hyperpolarization-activated cyclic nucleotide-gated ion channel in complex with cAMP.

Summary for 9R1T

Entry DOI	10.2210/pdb9r1t/pdb
Related	9R1U 9R1V
EMDB information	53514
Descriptor	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2,HCN112 holo, in complex with cAMP, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE (2 entities in total)
Functional Keywords	ion channel, hcn channel, pacemaker channel, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	292725.58
Authors	Zorzini, V.,Ulens, C. (deposition date: 2025-04-28, release date: 2026-05-27)
Primary citation	Zorzini, V.,Gallardo, R.,Brams, M.,Ulens, C. Interactions between CNBD and HCND domains control gating inhibition in HCN1 family. To Be Published,
Experimental method	ELECTRON MICROSCOPY (3.34 Å)

Structure validation