9QU4
Cryo-EM structure of the inward-open choline-bound state of choline/ethanolamine transporter FLVCR2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Immunoglobulin G-binding protein A,Choline/ethanolamine transporter FLVCR2 | polymer | 597 | 66364.5 | 1 | UniProt (P38507) UniProt (Q9UPI3) Pfam (PF02216) Pfam (PF07690) UniProt (by SIFTS) (P02976) | Homo sapiens (human) | IgG-binding protein A,Staphylococcal protein A,SpA,Calcium-chelate transporter,CCT,Feline leukemia virus subgroup C receptor-related protein 2,Heme transporter FLVCR2 |
| 2 | B (A) | CHOLINE ION | non-polymer | 104.2 | 1 | Chemie (CHT) |
Sequence modifications
A: -58 - 78 (UniProt: P38507)
A: 83 - 526 (UniProt: Q9UPI3)
| PDB | External Database | Details |
|---|---|---|
| Met -65 | - | initiating methionine |
| Gly -64 | - | expression tag |
| Pro -63 | - | expression tag |
| Met -62 | - | expression tag |
| Val -61 | - | expression tag |
| Asn -60 | - | expression tag |
| Glu -59 | - | expression tag |
| Ser -46 | Asn 171 | conflict |
| Leu -45 | Met 172 | conflict |
| Ala -35 | Gly 182 | conflict |
| - | Glu 206 | deletion |
| - | Ser 207 | deletion |
| - | Gln 208 | deletion |
| - | Ala 209 | deletion |
| - | Pro 210 | deletion |
| - | Lys 211 | deletion |
| - | Ala 212 | deletion |
| - | Asp 213 | deletion |
| - | Asn 214 | deletion |
| - | Lys 215 | deletion |
| - | Phe 216 | deletion |
| - | Asn 217 | deletion |
| - | Lys 218 | deletion |
| Ala -8 | Asn 222 | conflict |
| Ala 10 | Gly 240 | conflict |
| - | Asp 264 | deletion |
| - | Ala 265 | deletion |
| - | Gln 266 | deletion |
| - | Ala 267 | deletion |
| - | Pro 268 | deletion |
| - | Lys 269 | deletion |
| - | Ala 270 | deletion |
| - | Asp 271 | deletion |
| - | Asn 272 | deletion |
| - | Lys 273 | deletion |
| - | Phe 274 | deletion |
| - | Asn 275 | deletion |
| - | Lys 276 | deletion |
| Ala 37 | Asn 280 | conflict |
| Asn 49 | Thr 292 | conflict |
| Ala 55 | Gly 298 | conflict |
| Gln 66 | Val 309 | conflict |
| Ala 68 | Lys 311 | conflict |
| Asn 69 | Glu 312 | conflict |
| Leu 70 | Ile 313 | conflict |
| Glu 79 | - | linker |
| Leu 80 | - | linker |
| Gln 81 | - | linker |
| Lys 82 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gly 527 | - | expression tag |
| Leu 528 | - | expression tag |
| Val 529 | - | expression tag |
| Pro 530 | - | expression tag |
| Arg 531 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 66364.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 104.2 | |
| All* | Total formula weight | 66468.7 |
