9QU4

Cryo-EM structure of the inward-open choline-bound state of choline/ethanolamine transporter FLVCR2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0019865	molecular_function	immunoglobulin binding
A	0022857	molecular_function	transmembrane transporter activity
A	0055085	biological_process	transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	33
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	27
Details	Transmembrane: {"description":"Helical; Name=TM2","evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	13
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=TM3","evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	28
Details	Transmembrane: {"description":"Helical; Name=TM4","evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=TM5","evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	29
Details	Transmembrane: {"description":"Helical; Name=TM6","evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	30
Details	Transmembrane: {"description":"Helical; Name=TM7","evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	28
Details	Transmembrane: {"description":"Helical; Name=TM8","evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=TM9","evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	29
Details	Transmembrane: {"description":"Helical; Name=TM10","evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=TM11","evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=TM12","evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QCX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q91X85","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38778100","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QD0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---