9QPY
Structure of the Complement classical and lectin pathway C3 convertase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Complement C4-A | polymer | 1744 | 192993.2 | 3 | UniProt (P0C0L4) Pfam (PF21145) Pfam (PF07677) Pfam (PF01759) Pfam (PF01835) Pfam (PF17791) Pfam (PF17789) Pfam (PF07703) Pfam (PF01821) Pfam (PF00207) Pfam (PF07678) Pfam (PF22661) | Homo sapiens (human) | Acidic complement C4,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2 |
| 2 | D (D) | Anti-C4b nanobody B12 | polymer | 120 | 13322.9 | 1 | Lama glama | ||
| 3 | E (E) | Complement C2 | polymer | 752 | 83347.8 | 1 | UniProt (P06681) Pfam (PF00084) Pfam (PF00092) Pfam (PF00089) | Homo sapiens (human) | C3/C5 convertase |
| 4 | F, G, H, I, K... (A, B, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) | |||
| 5 | J (E) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) |
Sequence modifications
A, B, C: 1 - 1744 (UniProt: P0C0L4)
E: 1 - 752 (UniProt: P06681)
| PDB | External Database | Details |
|---|---|---|
| Ser 1201 | Thr 1201 | variant |
| PDB | External Database | Details |
|---|---|---|
| Ala 679 | Ser 679 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 675650.3 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1572.8 | |
| All* | Total formula weight | 677223.0 |
