9QKT

Cryo-EM structure of the CDK11B-cyclin L2-SAP30BP bound to OTS964 (conformation 1)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	SAP30-binding protein	polymer	311	34186.6	1	UniProt (Q9UHR5)	Homo sapiens (human)	Transcriptional regulator protein HCNGP
2	B (C)	Cyclin-L2	polymer	322	35690.5	1	UniProt (Q96S94)	Homo sapiens (human)	Paneth cell-enhanced expression protein
3	C (B)	Cyclin-dependent kinase 11B	polymer	442	50050.6	1	UniProt (P21127)	Homo sapiens (human)	Cell division cycle 2-like protein kinase 1,CLK-1,Cell division protein kinase 11B,Galactosyltransferase-associated protein kinase p58/GTA,PITSLRE serine/threonine-protein kinase CDC2L1,p58 CLK-1
4	D (B)	OTS964	non-polymer		392.5	1	Chemie (NK3)
5	E, F, G (A, C, B)	water	water		18.0	80	Chemie (HOH)

Sequence modifications

A: 1 - 308 (UniProt: Q9UHR5)

PDB	External Database	Details
Ser -2	-	expression tag
Asn -1	-	expression tag
Ala 0	-	expression tag

C: 1 - 319 (UniProt: Q96S94)

PDB	External Database	Details
Ser -2	-	expression tag
Asn -1	-	expression tag
Ala 0	-	expression tag

B: 357 - 795 (UniProt: P21127)

PDB	External Database	Details
Ser 354	-	expression tag
Asn 355	-	expression tag
Ala 356	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	119927.7
Non-Polymers*	Number of molecules	1
	Total formula weight	392.5
All*	Total formula weight	120320.2

*Water molecules are not included.