9QJJ
Cryo-EM structure of CDK2-cyclin A bound to OTS964
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclin-A2 | polymer | 435 | 48867.8 | 1 | UniProt (P20248) | Homo sapiens (human) | Cyclin-A,Cyclin A |
| 2 | B (B) | Cyclin-dependent kinase 2 | polymer | 301 | 34248.8 | 1 | UniProt (P24941) | Homo sapiens (human) | Cell division protein kinase 2,p33 protein kinase |
| 3 | C (B) | OTS964 | non-polymer | 392.5 | 1 | Chemie (NK3) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 55 | Chemie (HOH) |
Sequence modifications
A: 1 - 432 (UniProt: P20248)
B: 1 - 298 (UniProt: P24941)
| PDB | External Database | Details |
|---|---|---|
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Val 163 | Ile 163 | variant |
| PDB | External Database | Details |
|---|---|---|
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 83116.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 392.5 | |
| All* | Total formula weight | 83509.1 |
