9QAW
CryoEM structure of the human LRP2 receptor ectodomain in complex with LRPAP1
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, L (L, K) | Alpha-2-macroglobulin receptor-associated protein | polymer | 344 | 40404.4 | 2 | UniProt (P30533) Pfam (PF06400) Pfam (PF06401) | Homo sapiens (human) | Alpha-2-MRAP,Low density lipoprotein receptor-related protein-associated protein 1,RAP |
| 2 | B, C (A, B) | Low-density lipoprotein receptor-related protein 2 | polymer | 4473 | 502222.5 | 2 | UniProt (P98164) Pfam (PF00057) Pfam (PF00058) Pfam (PF14670) Pfam (PF07645) Pfam (PF24468) Pfam (PF12662) | Homo sapiens (human) | LRP-2,Glycoprotein 330,gp330,Megalin |
| 3 | D, G (D, E) | Unidentified peptide 1 | polymer | 10 | 869.1 | 2 | Homo sapiens | ||
| 4 | E, F, K (C, F, J) | Unidentified peptide 2 | polymer | 7 | 613.7 | 3 | Homo sapiens | ||
| 5 | H (H) | Unidentified peptide 3 | polymer | 12 | 1039.3 | 1 | Homo sapiens | ||
| 6 | I (I) | Unidentified peptide 4 | polymer | 8 | 698.9 | 1 | Homo sapiens | ||
| 7 | J (G) | Unidentified peptide 5 | polymer | 13 | 1124.4 | 1 | Homo sapiens | ||
| 8 | AA, BA, M, N, T... (a, b, M, N, T...) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 7 | In PDB GlyTouCan (G15407YE) | |||
| 9 | O, P, Q, R, S... (O, P, Q, R, S...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 9 | In PDB GlyTouCan (G42666HT) | |||
| 10 | CA, DA, EA, FB, GB... (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 19 | Chemie (NAG) | |||
| 11 | FA, GA (A) | beta-D-mannopyranose | non-polymer | 180.2 | 2 | Chemie (BMA) | |||
| 12 | MA, MB, NA, NB, OA... (A, B) | 2-acetamido-2-deoxy-beta-D-galactopyranose | non-polymer | 221.2 | 7 | Chemie (NGA) | |||
| 13 | AB, AC, BB, BC, CB... (A, B) | CALCIUM ION | non-polymer | 40.1 | 25 | Chemie (CA) | |||
| 14 | YB, ZA (B, A) | NICKEL (II) ION | non-polymer | 58.7 | 2 | Chemie (NI) |
Sequence modifications
L, K: 35 - 357 (UniProt: P30533)
A, B: 1 - 4423 (UniProt: P98164)
| PDB | External Database | Details |
|---|---|---|
| Met 33 | - | initiating methionine |
| Ser 34 | - | expression tag |
| Ala 358 | - | expression tag |
| Leu 359 | - | expression tag |
| Glu 360 | - | expression tag |
| Val 361 | - | expression tag |
| Leu 362 | - | expression tag |
| Phe 363 | - | expression tag |
| Gln 364 | - | expression tag |
| Gly 365 | - | expression tag |
| Pro 366 | - | expression tag |
| His 367 | - | expression tag |
| His 368 | - | expression tag |
| His 369 | - | expression tag |
| His 370 | - | expression tag |
| His 371 | - | expression tag |
| His 372 | - | expression tag |
| His 373 | - | expression tag |
| His 374 | - | expression tag |
| His 375 | - | expression tag |
| His 376 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 4424 | - | expression tag |
| Trp 4425 | - | expression tag |
| Ser 4426 | - | expression tag |
| His 4427 | - | expression tag |
| Pro 4428 | - | expression tag |
| Gln 4429 | - | expression tag |
| Phe 4430 | - | expression tag |
| Glu 4431 | - | expression tag |
| Lys 4432 | - | expression tag |
| Ala 4433 | - | expression tag |
| Gly 4434 | - | expression tag |
| Gly 4435 | - | expression tag |
| Gly 4436 | - | expression tag |
| Ser 4437 | - | expression tag |
| Gly 4438 | - | expression tag |
| Gly 4439 | - | expression tag |
| Gly 4440 | - | expression tag |
| Ser 4441 | - | expression tag |
| Gly 4442 | - | expression tag |
| Gly 4443 | - | expression tag |
| Gly 4444 | - | expression tag |
| Ser 4445 | - | expression tag |
| Trp 4446 | - | expression tag |
| Ser 4447 | - | expression tag |
| His 4448 | - | expression tag |
| Pro 4449 | - | expression tag |
| Gln 4450 | - | expression tag |
| Phe 4451 | - | expression tag |
| Glu 4452 | - | expression tag |
| Lys 4453 | - | expression tag |
| Gly 4454 | - | expression tag |
| Gly 4455 | - | expression tag |
| Gly 4456 | - | expression tag |
| Ser 4457 | - | expression tag |
| Gly 4458 | - | expression tag |
| Gly 4459 | - | expression tag |
| Gly 4460 | - | expression tag |
| Ser 4461 | - | expression tag |
| Gly 4462 | - | expression tag |
| Gly 4463 | - | expression tag |
| Gly 4464 | - | expression tag |
| Ser 4465 | - | expression tag |
| Trp 4466 | - | expression tag |
| Ser 4467 | - | expression tag |
| His 4468 | - | expression tag |
| Pro 4469 | - | expression tag |
| Gln 4470 | - | expression tag |
| Phe 4471 | - | expression tag |
| Glu 4472 | - | expression tag |
| Lys 4473 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 1091695.7 | |
| Branched | Number of molecules | 16 |
| Total formula weight | 7925.4 | |
| Non-Polymers* | Number of molecules | 55 |
| Total formula weight | 7231.1 | |
| All* | Total formula weight | 1106852.1 |
