Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9QAW

CryoEM structure of the human LRP2 receptor ectodomain in complex with LRPAP1

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
K	0001540	molecular_function	amyloid-beta binding
K	0002091	biological_process	negative regulation of receptor internalization
K	0005102	molecular_function	signaling receptor binding
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005768	cellular_component	endosome
K	0005783	cellular_component	endoplasmic reticulum
K	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
K	0005794	cellular_component	Golgi apparatus
K	0005796	cellular_component	Golgi lumen
K	0005801	cellular_component	cis-Golgi network
K	0005886	cellular_component	plasma membrane
K	0007165	biological_process	signal transduction
K	0009986	cellular_component	cell surface
K	0010916	biological_process	negative regulation of very-low-density lipoprotein particle clearance
K	0012505	cellular_component	endomembrane system
K	0031904	cellular_component	endosome lumen
K	0031982	cellular_component	vesicle
K	0035473	molecular_function	lipase binding
K	0048018	molecular_function	receptor ligand activity
K	0048019	molecular_function	receptor antagonist activity
K	0048237	cellular_component	rough endoplasmic reticulum lumen
K	0048259	biological_process	regulation of receptor-mediated endocytosis
K	0050750	molecular_function	low-density lipoprotein particle receptor binding
K	0070326	molecular_function	very-low-density lipoprotein particle receptor binding
K	0150093	biological_process	amyloid-beta clearance by transcytosis
K	1900116	biological_process	extracellular negative regulation of signal transduction
K	1900222	biological_process	negative regulation of amyloid-beta clearance
K	1900223	biological_process	positive regulation of amyloid-beta clearance
L	0001540	molecular_function	amyloid-beta binding
L	0002091	biological_process	negative regulation of receptor internalization
L	0005102	molecular_function	signaling receptor binding
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005768	cellular_component	endosome
L	0005783	cellular_component	endoplasmic reticulum
L	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
L	0005794	cellular_component	Golgi apparatus
L	0005796	cellular_component	Golgi lumen
L	0005801	cellular_component	cis-Golgi network
L	0005886	cellular_component	plasma membrane
L	0007165	biological_process	signal transduction
L	0009986	cellular_component	cell surface
L	0010916	biological_process	negative regulation of very-low-density lipoprotein particle clearance
L	0012505	cellular_component	endomembrane system
L	0031904	cellular_component	endosome lumen
L	0031982	cellular_component	vesicle
L	0035473	molecular_function	lipase binding
L	0048018	molecular_function	receptor ligand activity
L	0048019	molecular_function	receptor antagonist activity
L	0048237	cellular_component	rough endoplasmic reticulum lumen
L	0048259	biological_process	regulation of receptor-mediated endocytosis
L	0050750	molecular_function	low-density lipoprotein particle receptor binding
L	0070326	molecular_function	very-low-density lipoprotein particle receptor binding
L	0150093	biological_process	amyloid-beta clearance by transcytosis
L	1900116	biological_process	extracellular negative regulation of signal transduction
L	1900222	biological_process	negative regulation of amyloid-beta clearance
L	1900223	biological_process	positive regulation of amyloid-beta clearance

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Motif: {"description":"Prevents secretion from ER","evidences":[{"source":"PubMed","id":"7774585","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	72
Details	Domain: {"description":"LDL-receptor class A 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	92
Details	Repeat: {"description":"LDL-receptor class B 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	88
Details	Repeat: {"description":"LDL-receptor class B 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	82
Details	Repeat: {"description":"LDL-receptor class B 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	86
Details	Repeat: {"description":"LDL-receptor class B 7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	86
Details	Repeat: {"description":"LDL-receptor class B 8","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	72
Details	Domain: {"description":"LDL-receptor class A 8","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	72
Details	Domain: {"description":"LDL-receptor class A 9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	72
Details	Domain: {"description":"LDL-receptor class A 10","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	72
Details	Domain: {"description":"LDL-receptor class A 11","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	74
Details	Domain: {"description":"LDL-receptor class A 12","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	76
Details	Domain: {"description":"LDL-receptor class A 13","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	72
Details	Domain: {"description":"LDL-receptor class A 14","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	78
Details	Domain: {"description":"EGF-like 1; calcium-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 10","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	86
Details	Repeat: {"description":"LDL-receptor class B 11","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	88
Details	Repeat: {"description":"LDL-receptor class B 12","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	80
Details	Repeat: {"description":"LDL-receptor class B 13","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	82
Details	Domain: {"description":"EGF-like 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 14","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	98
Details	Repeat: {"description":"LDL-receptor class B 15","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	94
Details	Repeat: {"description":"LDL-receptor class B 16","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	82
Details	Repeat: {"description":"LDL-receptor class B 17","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	80
Details	Repeat: {"description":"LDL-receptor class B 18","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	98
Details	Repeat: {"description":"LDL-receptor class B 19","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	88
Details	Repeat: {"description":"LDL-receptor class B 20","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	86
Details	Repeat: {"description":"LDL-receptor class B 21","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	86
Details	Repeat: {"description":"LDL-receptor class B 22","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	92
Details	Repeat: {"description":"LDL-receptor class B 23","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	80
Details	Repeat: {"description":"LDL-receptor class B 24","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI37
Number of Residues	86
Details	Repeat: {"description":"LDL-receptor class B 25","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI38
Number of Residues	82
Details	Repeat: {"description":"LDL-receptor class B 26","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI39
Number of Residues	82
Details	Repeat: {"description":"LDL-receptor class B 27","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI40
Number of Residues	76
Details	Domain: {"description":"LDL-receptor class A 16","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI41
Number of Residues	72
Details	Domain: {"description":"LDL-receptor class A 17","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI42
Number of Residues	76
Details	Domain: {"description":"LDL-receptor class A 24","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI43
Number of Residues	72
Details	Domain: {"description":"LDL-receptor class A 25","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI44
Number of Residues	82
Details	Domain: {"description":"EGF-like 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI45
Number of Residues	80
Details	Domain: {"description":"EGF-like 4; calcium-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI46
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 28","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI47
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 29","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI48
Number of Residues	86
Details	Repeat: {"description":"LDL-receptor class B 30","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI49
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 31","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI50
Number of Residues	80
Details	Repeat: {"description":"LDL-receptor class B 32","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI51
Number of Residues	76
Details	Domain: {"description":"LDL-receptor class A 26","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI52
Number of Residues	76
Details	Domain: {"description":"LDL-receptor class A 27","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI53
Number of Residues	76
Details	Domain: {"description":"LDL-receptor class A 28","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI54
Number of Residues	76
Details	Domain: {"description":"LDL-receptor class A 29","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI55
Number of Residues	76
Details	Domain: {"description":"LDL-receptor class A 30","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI56
Number of Residues	74
Details	Domain: {"description":"LDL-receptor class A 31","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI57
Number of Residues	72
Details	Domain: {"description":"LDL-receptor class A 32","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI58
Number of Residues	72
Details	Domain: {"description":"LDL-receptor class A 33","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI59
Number of Residues	38
Details	Domain: {"description":"LDL-receptor class A 34","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI60
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 33","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI61
Number of Residues	86
Details	Repeat: {"description":"LDL-receptor class B 34","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI62
Number of Residues	82
Details	Repeat: {"description":"LDL-receptor class B 35","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI63
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23275343","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2M0P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI64
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P98158","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI65
Number of Residues	56
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)