9Q3L
CryoEM structure of beta2-adrenergic receptor dimer mediated by a biased allosteric modulator in lipid nanodisc
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Beta-2 adrenergic receptor | polymer | 460 | 51767.2 | 2 | UniProt (P07550) | Homo sapiens (human) | Beta-2 adrenoreceptor,Beta-2 adrenoceptor |
| 2 | C, G (A, B) | TETRADECANE | non-polymer | 198.4 | 2 | Chemie (C14) PubChem (12389) | |||
| 3 | D, H (A, B) | EICOSANE | non-polymer | 282.5 | 2 | Chemie (LFA) PubChem (8222) | |||
| 4 | E, I (A, B) | 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one | non-polymer | 370.4 | 2 | Chemie (P0G) PubChem (49837874) | |||
| 5 | F, J (A, B) | 6-bromo-N~4~-cyclohexyl-N~2~-(3,4-difluorophenyl)quinazoline-2,4-diamine | non-polymer | 433.3 | 2 | Chemie (A1CNS) |
Sequence modifications
A, B: -6 - 421 (UniProt: P07550)
| PDB | External Database | Details |
|---|---|---|
| Met -30 | - | expression tag |
| Lys -29 | - | expression tag |
| Thr -28 | - | expression tag |
| Ile -27 | - | expression tag |
| Ile -26 | - | expression tag |
| Ala -25 | - | expression tag |
| Leu -24 | - | expression tag |
| Ser -23 | - | expression tag |
| Tyr -22 | - | expression tag |
| Ile -21 | - | expression tag |
| Phe -20 | - | expression tag |
| Cys -19 | - | expression tag |
| Leu -18 | - | expression tag |
| Val -17 | - | expression tag |
| Phe -16 | - | expression tag |
| Ala -15 | - | expression tag |
| Asp -14 | - | expression tag |
| Tyr -13 | - | expression tag |
| Lys -12 | - | expression tag |
| Asp -11 | - | expression tag |
| Asp -10 | - | expression tag |
| Asp -9 | - | expression tag |
| Asp -8 | - | expression tag |
| Ala -7 | - | expression tag |
| Arg 9 | Gly 16 | conflict |
| Glu 18 | - | insertion |
| Asn 19 | - | insertion |
| Leu 20 | - | insertion |
| Tyr 21 | - | insertion |
| Phe 22 | - | insertion |
| Gln 23 | - | insertion |
| Gly 24 | - | insertion |
| Gln 27 | Glu 27 | conflict |
| Thr 96 | Met 96 | conflict |
| Thr 98 | Met 98 | conflict |
| Glu 187 | Asn 187 | conflict |
| Leu 366 | - | insertion |
| Glu 367 | - | insertion |
| Val 368 | - | insertion |
| Leu 369 | - | insertion |
| Phe 370 | - | insertion |
| Gln 371 | - | insertion |
| Gly 372 | - | insertion |
| Pro 373 | - | insertion |
| Ala 386 | Cys 378 | conflict |
| Ala 414 | Cys 406 | conflict |
| Glu 422 | - | expression tag |
| Thr 423 | - | expression tag |
| Ser 424 | - | expression tag |
| Gln 425 | - | expression tag |
| Val 426 | - | expression tag |
| Ala 427 | - | expression tag |
| Pro 428 | - | expression tag |
| Ala 429 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 103534.5 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2569.3 | |
| All* | Total formula weight | 106103.8 |
