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9Q31

RIP1 kinase domain in complex with GDC-8264

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Receptor-interacting serine/threonine-protein kinase 1polymer29633612.92UniProt (Q13546)
Pfam (PF07714)
Homo sapiens (human)Cell death protein RIP,Receptor-interacting protein 1,RIP-1
2C, N
(A, B)
cyclopropyl[(4R,5S,7S)-7-fluoro-5-phenyl-6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazol-2-yl]methanonenon-polymer271.32Chemie (A1CNU)
3D, E, O, P
(A, B)
BROMIDE IONnon-polymer79.94Chemie (BR)
4F, Q, R
(A, B)
CHLORIDE IONnon-polymer35.53Chemie (CL)
5G, H, I, J, K...
(A, B)
SODIUM IONnon-polymer23.09Chemie (NA)
6M
(B)
PROPANEnon-polymer44.11Chemie (TME)
7V, W
(A, B)
waterwater18.0281Chemie (HOH)
Sequence modifications
A, B: 1 - 294 (UniProt: Q13546)
PDBExternal DatabaseDetails
Gly -1-expression tag
Ser 0-expression tag
Ala 34Cys 34engineered mutation
Ala 127Cys 127engineered mutation
Ala 233Cys 233engineered mutation
Ala 240Cys 240engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight67225.7
Non-Polymers*Number of molecules19
Total formula weight1219.6
All*Total formula weight68445.3
*Water molecules are not included.

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PDB entries from 2026-02-25

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