9PXR
Human malic enzyme 1 complex with inhibitor NPD-389 at 2.3 Angstrom.
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | NADP-dependent malic enzyme | polymer | 580 | 65294.6 | 4 | UniProt (P48163) | Homo sapiens (human) | NADP-ME,Malic enzyme 1 |
| 2 | E, I, M, S (A, B, C, D) | 2~3~,2~6~-dihydroxy-1~4~,3~4~-dimethoxy[1~1~,2~1~:2~4~,3~1~-terphenyl]-2~2~,2~5~-dione | non-polymer | 352.3 | 4 | Chemie (A1AE5) PubChem (631768) | |||
| 3 | F, J, N, T (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) PubChem (888) | |||
| 4 | G, K, O, U (A, B, C, D) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) | |||
| 5 | H, L, P, Q (A, B, C) | SODIUM ION | non-polymer | 23.0 | 4 | Chemie (NA) PubChem (923) | |||
| 6 | R (C) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) PubChem (1061) | |||
| 7 | V, W, X, Y (A, B, C, D) | water | water | 18.0 | 750 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 11 - 582 (UniProt: P48163)
| PDB | External Database | Details |
|---|---|---|
| Leu 583 | - | expression tag |
| Glu 584 | - | expression tag |
| His 585 | - | expression tag |
| His 586 | - | expression tag |
| His 587 | - | expression tag |
| His 588 | - | expression tag |
| His 589 | - | expression tag |
| His 590 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 261178.2 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 4667.1 | |
| All* | Total formula weight | 265845.3 |
