9PWQ

Cryo-EM structure of receptor tyrosine kinase ROS1 extracellular domain in complex with NELL2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Proto-oncogene tyrosine-protein kinase ROS	polymer	1853	207672.3	1	UniProt (Q78DX7)	Mus musculus (house mouse)	Proto-oncogene c-Ros,Proto-oncogene c-Ros-1,Receptor tyrosine kinase c-ros oncogene 1,c-Ros receptor tyrosine kinase
2	B (B)	Protein kinase C-binding protein NELL2	polymer	830	92446.1	1	UniProt (Q99435)	Homo sapiens (human)	NEL-like protein 2,Nel-related protein 2
3	C, D, E, F, G... (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	10	Chemie (NAG)

Sequence modifications

A: 29 - 1847 (UniProt: Q78DX7)

PDB	External Database	Details
Gly 1848	-	expression tag
Gly 1849	-	expression tag
Gly 1850	-	expression tag
Ser 1851	-	expression tag
Ser 1852	-	expression tag
Ala 1853	-	expression tag
Trp 1854	-	expression tag
Ser 1855	-	expression tag
His 1856	-	expression tag
Pro 1857	-	expression tag
Gln 1858	-	expression tag
Phe 1859	-	expression tag
Glu 1860	-	expression tag
Lys 1861	-	expression tag
Gly 1862	-	expression tag
Gly 1863	-	expression tag
Gly 1864	-	expression tag
Ser 1865	-	expression tag
Gly 1866	-	expression tag
Gly 1867	-	expression tag
Gly 1868	-	expression tag
Ser 1869	-	expression tag
Gly 1870	-	expression tag
Gly 1871	-	expression tag
Ser 1872	-	expression tag
Ala 1873	-	expression tag
Trp 1874	-	expression tag
Ser 1875	-	expression tag
His 1876	-	expression tag
Pro 1877	-	expression tag
Gln 1878	-	expression tag
Phe 1879	-	expression tag
Glu 1880	-	expression tag
Lys 1881	-	expression tag

B: 22 - 816 (UniProt: Q99435)

PDB	External Database	Details
Gly 817	-	expression tag
Gly 818	-	expression tag
Gly 819	-	expression tag
Gly 820	-	expression tag
Ser 821	-	expression tag
Ser 822	-	expression tag
Ala 823	-	expression tag
Trp 824	-	expression tag
Ser 825	-	expression tag
His 826	-	expression tag
Pro 827	-	expression tag
Gln 828	-	expression tag
Phe 829	-	expression tag
Glu 830	-	expression tag
Lys 831	-	expression tag
Gly 832	-	expression tag
Gly 833	-	expression tag
Gly 834	-	expression tag
Ser 835	-	expression tag
Gly 836	-	expression tag
Gly 837	-	expression tag
Gly 838	-	expression tag
Ser 839	-	expression tag
Gly 840	-	expression tag
Gly 841	-	expression tag
Ser 842	-	expression tag
Ala 843	-	expression tag
Trp 844	-	expression tag
Ser 845	-	expression tag
His 846	-	expression tag
Pro 847	-	expression tag
Gln 848	-	expression tag
Phe 849	-	expression tag
Glu 850	-	expression tag
Lys 851	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	300118.5
Non-Polymers*	Number of molecules	10
	Total formula weight	2212.1
All*	Total formula weight	302330.6

*Water molecules are not included.