9PWO

Pig Ryanodine Receptor 1 R615C Mutant: Atorvastatin Bound Open Conformation

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G (A, G, M, S)	Ryanodine receptor 1	polymer	5035	565935.1	4	UniProt (P16960) Pfam (PF08709) Pfam (PF01365) Pfam (PF02026) Pfam (PF08454) Pfam (PF06459) Pfam (PF00520) Pfam (PF02815) Pfam (PF00622) Pfam (PF21119)	Sus scrofa (pig)	RYR-1,RyR1,Skeletal muscle calcium release channel,Skeletal muscle ryanodine receptor,Skeletal muscle-type ryanodine receptor,Type 1 ryanodine receptor
2	B, D, F, H (B, H, N, T)	Peptidyl-prolyl cis-trans isomerase FKBP1B	polymer	111	12070.8	4	UniProt (P68106) Pfam (PF00254)	Homo sapiens (human)	PPIase FKBP1B,12.6 kDa FK506-binding protein,12.6 kDa FKBP,FKBP-12.6,FK506-binding protein 1B,FKBP-1B,Immunophilin FKBP12.6,Rotamase,h-FKBP-12
3	AA, I, O, U (S, A, G, M)	CAFFEINE	non-polymer		194.2	4	Chemie (CFF)
4	BA, J, P, V (S, A, G, M)	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
5	CA, DA, EA, K, L... (S, A, G, M)	7-[2-(4-FLUORO-PHENYL)-5-ISOPROPYL-3-PHENYL-4-PHENYLCARBAMOYL-PYRROL-1-YL]- 3,5-DIHYDROXY-HEPTANOIC ACID	non-polymer		558.6	12	Chemie (117)
6	FA, N, T, Z (S, A, G, M)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)

Sequence modifications

A, G, M, S: 1 - 5035 (UniProt: P16960)

PDB	External Database	Details
Cys 615	Arg 615	variant

B, H, N, T: 1 - 108 (UniProt: P68106)

PDB	External Database	Details
Ser -2	-	expression tag
Asn -1	-	expression tag
Ala 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	2312023.3
Non-Polymers*	Number of molecules	24
	Total formula weight	7902.4
All*	Total formula weight	2319925.7

*Water molecules are not included.