9PWO

Pig Ryanodine Receptor 1 R615C Mutant: Atorvastatin Bound Open Conformation

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003151	biological_process	outflow tract morphogenesis
A	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
A	0005245	molecular_function	voltage-gated calcium channel activity
A	0005262	molecular_function	calcium channel activity
A	0005509	molecular_function	calcium ion binding
A	0005516	molecular_function	calmodulin binding
A	0005524	molecular_function	ATP binding
A	0005790	cellular_component	smooth endoplasmic reticulum
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0006936	biological_process	muscle contraction
A	0006941	biological_process	striated muscle contraction
A	0014802	cellular_component	terminal cisterna
A	0014808	biological_process	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A	0016529	cellular_component	sarcoplasmic reticulum
A	0019722	biological_process	calcium-mediated signaling
A	0030018	cellular_component	Z disc
A	0031000	biological_process	response to caffeine
A	0031090	cellular_component	organelle membrane
A	0033017	cellular_component	sarcoplasmic reticulum membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034704	cellular_component	calcium channel complex
A	0042383	cellular_component	sarcolemma
A	0043588	biological_process	skin development
A	0043931	biological_process	ossification involved in bone maturation
A	0046872	molecular_function	metal ion binding
A	0048741	biological_process	skeletal muscle fiber development
A	0051209	biological_process	release of sequestered calcium ion into cytosol
A	0051289	biological_process	protein homotetramerization
A	0070588	biological_process	calcium ion transmembrane transport
A	0071277	biological_process	cellular response to calcium ion
A	0071313	biological_process	cellular response to caffeine
A	1990425	cellular_component	ryanodine receptor complex
B	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
B	0005102	molecular_function	signaling receptor binding
B	0005246	molecular_function	calcium channel regulator activity
B	0005515	molecular_function	protein binding
B	0005528	molecular_function	FK506 binding
B	0005737	cellular_component	cytoplasm
B	0006457	biological_process	protein folding
B	0006458	biological_process	'de novo' protein folding
B	0010459	biological_process	negative regulation of heart rate
B	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B	0016020	cellular_component	membrane
B	0016529	cellular_component	sarcoplasmic reticulum
B	0016853	molecular_function	isomerase activity
B	0019722	biological_process	calcium-mediated signaling
B	0019855	molecular_function	calcium channel inhibitor activity
B	0030018	cellular_component	Z disc
B	0033017	cellular_component	sarcoplasmic reticulum membrane
B	0034704	cellular_component	calcium channel complex
B	0042026	biological_process	protein refolding
B	0044325	molecular_function	transmembrane transporter binding
B	0050849	biological_process	negative regulation of calcium-mediated signaling
B	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
B	0051604	biological_process	protein maturation
B	0051775	biological_process	response to redox state
B	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
G	0000166	molecular_function	nucleotide binding
G	0003151	biological_process	outflow tract morphogenesis
G	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
G	0005245	molecular_function	voltage-gated calcium channel activity
G	0005262	molecular_function	calcium channel activity
G	0005509	molecular_function	calcium ion binding
G	0005516	molecular_function	calmodulin binding
G	0005524	molecular_function	ATP binding
G	0005790	cellular_component	smooth endoplasmic reticulum
G	0005886	cellular_component	plasma membrane
G	0006811	biological_process	monoatomic ion transport
G	0006816	biological_process	calcium ion transport
G	0006936	biological_process	muscle contraction
G	0006941	biological_process	striated muscle contraction
G	0014802	cellular_component	terminal cisterna
G	0014808	biological_process	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
G	0016529	cellular_component	sarcoplasmic reticulum
G	0019722	biological_process	calcium-mediated signaling
G	0030018	cellular_component	Z disc
G	0031000	biological_process	response to caffeine
G	0031090	cellular_component	organelle membrane
G	0033017	cellular_component	sarcoplasmic reticulum membrane
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0034704	cellular_component	calcium channel complex
G	0042383	cellular_component	sarcolemma
G	0043588	biological_process	skin development
G	0043931	biological_process	ossification involved in bone maturation
G	0046872	molecular_function	metal ion binding
G	0048741	biological_process	skeletal muscle fiber development
G	0051209	biological_process	release of sequestered calcium ion into cytosol
G	0051289	biological_process	protein homotetramerization
G	0070588	biological_process	calcium ion transmembrane transport
G	0071277	biological_process	cellular response to calcium ion
G	0071313	biological_process	cellular response to caffeine
G	1990425	cellular_component	ryanodine receptor complex
H	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
H	0005102	molecular_function	signaling receptor binding
H	0005246	molecular_function	calcium channel regulator activity
H	0005515	molecular_function	protein binding
H	0005528	molecular_function	FK506 binding
H	0005737	cellular_component	cytoplasm
H	0006457	biological_process	protein folding
H	0006458	biological_process	'de novo' protein folding
H	0010459	biological_process	negative regulation of heart rate
H	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H	0016020	cellular_component	membrane
H	0016529	cellular_component	sarcoplasmic reticulum
H	0016853	molecular_function	isomerase activity
H	0019722	biological_process	calcium-mediated signaling
H	0019855	molecular_function	calcium channel inhibitor activity
H	0030018	cellular_component	Z disc
H	0033017	cellular_component	sarcoplasmic reticulum membrane
H	0034704	cellular_component	calcium channel complex
H	0042026	biological_process	protein refolding
H	0044325	molecular_function	transmembrane transporter binding
H	0050849	biological_process	negative regulation of calcium-mediated signaling
H	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
H	0051604	biological_process	protein maturation
H	0051775	biological_process	response to redox state
H	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
M	0000166	molecular_function	nucleotide binding
M	0003151	biological_process	outflow tract morphogenesis
M	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
M	0005245	molecular_function	voltage-gated calcium channel activity
M	0005262	molecular_function	calcium channel activity
M	0005509	molecular_function	calcium ion binding
M	0005516	molecular_function	calmodulin binding
M	0005524	molecular_function	ATP binding
M	0005790	cellular_component	smooth endoplasmic reticulum
M	0005886	cellular_component	plasma membrane
M	0006811	biological_process	monoatomic ion transport
M	0006816	biological_process	calcium ion transport
M	0006936	biological_process	muscle contraction
M	0006941	biological_process	striated muscle contraction
M	0014802	cellular_component	terminal cisterna
M	0014808	biological_process	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
M	0016529	cellular_component	sarcoplasmic reticulum
M	0019722	biological_process	calcium-mediated signaling
M	0030018	cellular_component	Z disc
M	0031000	biological_process	response to caffeine
M	0031090	cellular_component	organelle membrane
M	0033017	cellular_component	sarcoplasmic reticulum membrane
M	0034220	biological_process	monoatomic ion transmembrane transport
M	0034704	cellular_component	calcium channel complex
M	0042383	cellular_component	sarcolemma
M	0043588	biological_process	skin development
M	0043931	biological_process	ossification involved in bone maturation
M	0046872	molecular_function	metal ion binding
M	0048741	biological_process	skeletal muscle fiber development
M	0051209	biological_process	release of sequestered calcium ion into cytosol
M	0051289	biological_process	protein homotetramerization
M	0070588	biological_process	calcium ion transmembrane transport
M	0071277	biological_process	cellular response to calcium ion
M	0071313	biological_process	cellular response to caffeine
M	1990425	cellular_component	ryanodine receptor complex
N	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
N	0005102	molecular_function	signaling receptor binding
N	0005246	molecular_function	calcium channel regulator activity
N	0005515	molecular_function	protein binding
N	0005528	molecular_function	FK506 binding
N	0005737	cellular_component	cytoplasm
N	0006457	biological_process	protein folding
N	0006458	biological_process	'de novo' protein folding
N	0010459	biological_process	negative regulation of heart rate
N	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
N	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
N	0016020	cellular_component	membrane
N	0016529	cellular_component	sarcoplasmic reticulum
N	0016853	molecular_function	isomerase activity
N	0019722	biological_process	calcium-mediated signaling
N	0019855	molecular_function	calcium channel inhibitor activity
N	0030018	cellular_component	Z disc
N	0033017	cellular_component	sarcoplasmic reticulum membrane
N	0034704	cellular_component	calcium channel complex
N	0042026	biological_process	protein refolding
N	0044325	molecular_function	transmembrane transporter binding
N	0050849	biological_process	negative regulation of calcium-mediated signaling
N	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
N	0051604	biological_process	protein maturation
N	0051775	biological_process	response to redox state
N	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
S	0000166	molecular_function	nucleotide binding
S	0003151	biological_process	outflow tract morphogenesis
S	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
S	0005245	molecular_function	voltage-gated calcium channel activity
S	0005262	molecular_function	calcium channel activity
S	0005509	molecular_function	calcium ion binding
S	0005516	molecular_function	calmodulin binding
S	0005524	molecular_function	ATP binding
S	0005790	cellular_component	smooth endoplasmic reticulum
S	0005886	cellular_component	plasma membrane
S	0006811	biological_process	monoatomic ion transport
S	0006816	biological_process	calcium ion transport
S	0006936	biological_process	muscle contraction
S	0006941	biological_process	striated muscle contraction
S	0014802	cellular_component	terminal cisterna
S	0014808	biological_process	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
S	0016529	cellular_component	sarcoplasmic reticulum
S	0019722	biological_process	calcium-mediated signaling
S	0030018	cellular_component	Z disc
S	0031000	biological_process	response to caffeine
S	0031090	cellular_component	organelle membrane
S	0033017	cellular_component	sarcoplasmic reticulum membrane
S	0034220	biological_process	monoatomic ion transmembrane transport
S	0034704	cellular_component	calcium channel complex
S	0042383	cellular_component	sarcolemma
S	0043588	biological_process	skin development
S	0043931	biological_process	ossification involved in bone maturation
S	0046872	molecular_function	metal ion binding
S	0048741	biological_process	skeletal muscle fiber development
S	0051209	biological_process	release of sequestered calcium ion into cytosol
S	0051289	biological_process	protein homotetramerization
S	0070588	biological_process	calcium ion transmembrane transport
S	0071277	biological_process	cellular response to calcium ion
S	0071313	biological_process	cellular response to caffeine
S	1990425	cellular_component	ryanodine receptor complex
T	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
T	0005102	molecular_function	signaling receptor binding
T	0005246	molecular_function	calcium channel regulator activity
T	0005515	molecular_function	protein binding
T	0005528	molecular_function	FK506 binding
T	0005737	cellular_component	cytoplasm
T	0006457	biological_process	protein folding
T	0006458	biological_process	'de novo' protein folding
T	0010459	biological_process	negative regulation of heart rate
T	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
T	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
T	0016020	cellular_component	membrane
T	0016529	cellular_component	sarcoplasmic reticulum
T	0016853	molecular_function	isomerase activity
T	0019722	biological_process	calcium-mediated signaling
T	0019855	molecular_function	calcium channel inhibitor activity
T	0030018	cellular_component	Z disc
T	0033017	cellular_component	sarcoplasmic reticulum membrane
T	0034704	cellular_component	calcium channel complex
T	0042026	biological_process	protein refolding
T	0044325	molecular_function	transmembrane transporter binding
T	0050849	biological_process	negative regulation of calcium-mediated signaling
T	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
T	0051604	biological_process	protein maturation
T	0051775	biological_process	response to redox state
T	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"UniProtKB","id":"P11716","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"UniProtKB","id":"P11716","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	88
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"UniProtKB","id":"P11716","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	168
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"UniProtKB","id":"P11716","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	64
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"UniProtKB","id":"P11716","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	56
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"P11716","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"UniProtKB","id":"P11716","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	76
Details	Intramembrane: {"description":"Pore-forming","evidences":[{"source":"UniProtKB","id":"P11716","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"UniProtKB","id":"P11716","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	220
Details	Domain: {"description":"MIR 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	180
Details	Domain: {"description":"MIR 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	216
Details	Domain: {"description":"MIR 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	252
Details	Domain: {"description":"MIR 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	864
Details	Domain: {"description":"B30.2/SPRY 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00548","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	452
Details	Repeat: {"description":"1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	112
Details	Domain: {"description":"EF-hand","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	44
Details	Region: {"description":"Interaction with FKBP1A","evidences":[{"source":"UniProtKB","id":"P11716","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	24
Details	Motif: {"description":"Selectivity filter","evidences":[{"source":"UniProtKB","id":"P11716","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	76
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P11716","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"F1LMY4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P21817","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P21817","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	352
Details	Domain: {"description":"PPIase FKBP-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00277","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---