9PRU

Complex of the 3G8 Fab bound to Fc gamma receptor 3a / CD16a F158 allotype

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G (A, C, E, G)	3G8 Fab light chain	polymer	218	23953.3	4		Mus musculus (mouse)
2	B, D, F, H (B, D, F, H)	3G8 Fab Heavy Chain	polymer	221	23677.7	4		Mus musculus (mouse)
3	I, J, K, L (W, X, Y, Z)	Low affinity immunoglobulin gamma Fc region receptor III-A	polymer	175	20118.5	4	UniProt (P08637) Pfam (PF13895)	Homo sapiens (human)	IgG Fc receptor III-A,CD16-II,CD16a antigen,Fc-gamma RIII-alpha,Fc-gamma RIII,Fc-gamma RIIIa,FcRIII,FcRIIIa,FcgammaRIIIA,FcR-10,IgG Fc receptor III-2
4	M, N, P (I, J, L)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	3	In PDB GlyTouCan (G15407YE)
5	O (K)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
6	Q, R, T (A, C, E)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
7	S, U, W (E, G, H)	SODIUM ION	non-polymer		23.0	3	Chemie (NA)
8	V (G)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
9	AA, X, Y, Z (Z, W, X, Y)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
10	BA, CA, DA, EA, FA... (A, B, C, D, E...)	water	water		18.0	1245	Chemie (HOH)

Sequence modifications

W, X, Y, Z: 1 - 175 (UniProt: P08637)

PDB	External Database	Details
Gln 38	Asn 56	engineered mutation
Gln 74	Asn 92	engineered mutation
Gln 169	Asn 187	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	270997.6
Branched	Number of molecules	4
	Total formula weight	2184.0
Non-Polymers*	Number of molecules	11
	Total formula weight	1265.5
All*	Total formula weight	274447.1

*Water molecules are not included.