9PI9

Sacituzumab Fab bound to Trop2 Dimer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Sacituzumab Heavy Chain	polymer	226	24144.0	2		Homo sapiens (human)
2	B, D (B, D)	Sacituzumab Light Chain	polymer	214	23362.0	2		Homo sapiens (human)
3	E, F (E, F)	Tumor-associated calcium signal transducer 2	polymer	250	28381.3	2	UniProt (P09758) Pfam (PF18635) Pfam (PF00086) Pfam (PF21283)	Homo sapiens (human)	Cell surface glycoprotein Trop-2,Membrane component chromosome 1 surface marker 1,Pancreatic carcinoma marker protein GA733-1
4	G (G)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
5	H, I, J, K, L... (A, B, C, D, E)	1,2-ETHANEDIOL	non-polymer		62.1	12	Chemie (EDO)
6	P (C)	alpha-D-mannopyranose	non-polymer		180.2	1	Chemie (MAN)
7	T (E)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
8	U, W (E, F)	CITRIC ACID	non-polymer		192.1	2	Chemie (CIT)
9	AA, BA, CA, X, Y... (D, E, F, A, B...)	water	water		18.0	1252	Chemie (HOH)

Sequence modifications

E, F: 31 - 274 (UniProt: P09758)

PDB	External Database	Details
Gln 120	Asn 120	conflict
Gln 208	Asn 208	conflict
His 275	-	expression tag
His 276	-	expression tag
His 277	-	expression tag
His 278	-	expression tag
His 279	-	expression tag
His 280	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	151774.5
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	16
	Total formula weight	1530.4
All*	Total formula weight	153729.4

*Water molecules are not included.