9PHV

Crystal structure of human KDM2A with substrate competitive inhibitor 183c

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Lysine-specific demethylase 2A	polymer	383	45338.0	1	UniProt (Q9Y2K7) Pfam (PF17811)	Homo sapiens (human)	CXXC-type zinc finger protein 8,F-box and leucine-rich repeat protein 11,F-box protein FBL7,F-box protein Lilina,F-box/LRR-repeat protein 11,JmjC domain-containing histone demethylation protein 1A,[Histone-H3]-lysine-36 demethylase 1A
2	B (D)	Lysine-specific demethylase 2A	polymer	69	7693.0	1	UniProt (Q9Y2K7)	Homo sapiens (human)	CXXC-type zinc finger protein 8,F-box and leucine-rich repeat protein 11,F-box protein FBL7,F-box protein Lilina,F-box/LRR-repeat protein 11,JmjC domain-containing histone demethylation protein 1A,[Histone-H3]-lysine-36 demethylase 1A
3	C (A)	2-OXOGLUTARIC ACID	non-polymer		146.1	1	Chemie (AKG) PubChem (51)
4	D (A)	{6-[(3R,4R)-1-cyclobutyl-4-ethylpiperidine-3-carbonyl]-2-methoxynaphthalen-1-yl}acetonitrile	non-polymer		390.5	1	Chemie (A1CIP)
5	E, I (A, D)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL) PubChem (753)
6	F (A)	NICKEL (II) ION	non-polymer		58.7	1	Chemie (NI) PubChem (934)
7	G (D)	2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL	non-polymer		122.1	1	Chemie (TRS) PubChem (3777159)
8	H (D)	DIMETHYL SULFOXIDE	non-polymer		78.1	1	Chemie (DMS) PubChem (679)
9	J, K (A, D)	water	water		18.0	99	Chemie (HOH)

Sequence modifications

A: 2 - 383 (UniProt: Q9Y2K7)

PDB	External Database	Details
Gly 1	-	expression tag

D: 450 - 517 (UniProt: Q9Y2K7)

PDB	External Database	Details
Met 449	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	53031.0
Non-Polymers*	Number of molecules	7
	Total formula weight	979.8
All*	Total formula weight	54010.7

*Water molecules are not included.