9PE1
Structure of beta-1,3-glucan synthase in complex with caspofungin, Rho1 and long glucan
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 1,3-beta-glucan synthase component FKS1 | polymer | 1931 | 221252.5 | 1 | UniProt (P38631) Pfam (PF14288) Pfam (PF23605) Pfam (PF02364) | Saccharomyces cerevisiae (brewer's yeast) | 1,3-beta-D-glucan-UDP glucosyltransferase,Calcineurin dependent protein 1,Calcofluor white hypersensitivity protein 53,Echinocandin target gene protein 1,FK506 sensitivity protein 1,Glucan synthase of cerevisiae protein 1,Papulacandin B resistance protein 1 |
| 2 | B (E) | GTP-binding protein RHO1 | polymer | 235 | 26145.7 | 1 | UniProt (P06780) Pfam (PF00071) | Saccharomyces cerevisiae (brewer's yeast) | Rho-type GTPase 1 |
| 3 | C (G) | Gsr1p | polymer | 197 | 22209.7 | 1 | UniProt (Q03559) Pfam (PF10295) | Saccharomyces cerevisiae (brewer's yeast) | |
| 4 | D (H) | Caspofungin | polymer | 6 | 872.9 | 1 | synthetic construct | ||
| 5 | E (D) | beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose | branched | 2774.4 | 1 | In PDB | |||
| 6 | F (K) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 7 | G (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) PubChem (24139) | |||
| 8 | AA, BA, CA, DA, EA... (A, H) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 29 | Chemie (Y01) PubChem (65082) | |||
| 9 | L (A) | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 1 | Chemie (3PE) | |||
| 10 | KA (A) | URIDINE-5'-DIPHOSPHATE | non-polymer | 404.2 | 1 | Chemie (UDP) | |||
| 11 | LA (E) | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE | non-polymer | 539.2 | 1 | Chemie (GSP) | |||
| 12 | MA (H) | (10R,12S)-10,12-dimethyltetradecanoic acid | non-polymer | 256.4 | 1 | Chemie (A1CHR) PubChem (12050963) | |||
| 13 | OA (A) | water | water | 18.0 | 9 | Chemie (HOH) |
Sequence modifications
A: 1 - 1876 (UniProt: P38631)
E: 2 - 209 (UniProt: P06780)
| PDB | External Database | Details |
|---|---|---|
| Leu 1877 | - | expression tag |
| Glu 1878 | - | expression tag |
| Val 1879 | - | expression tag |
| Leu 1880 | - | expression tag |
| Phe 1881 | - | expression tag |
| Gln 1882 | - | expression tag |
| Gly 1883 | - | expression tag |
| Pro 1884 | - | expression tag |
| Ala 1885 | - | expression tag |
| Ala 1886 | - | expression tag |
| Ala 1887 | - | expression tag |
| Gly 1888 | - | expression tag |
| Ser 1889 | - | expression tag |
| Ala 1890 | - | expression tag |
| Gly 1891 | - | expression tag |
| Ser 1892 | - | expression tag |
| Ala 1893 | - | expression tag |
| Ala 1894 | - | expression tag |
| Gly 1895 | - | expression tag |
| Ser 1896 | - | expression tag |
| Gly 1897 | - | expression tag |
| Glu 1898 | - | expression tag |
| Phe 1899 | - | expression tag |
| Asp 1900 | - | expression tag |
| Tyr 1901 | - | expression tag |
| Lys 1902 | - | expression tag |
| Asp 1903 | - | expression tag |
| His 1904 | - | expression tag |
| Asp 1905 | - | expression tag |
| Gly 1906 | - | expression tag |
| Asp 1907 | - | expression tag |
| Tyr 1908 | - | expression tag |
| Lys 1909 | - | expression tag |
| Asp 1910 | - | expression tag |
| His 1911 | - | expression tag |
| Asp 1912 | - | expression tag |
| Ile 1913 | - | expression tag |
| Asp 1914 | - | expression tag |
| Tyr 1915 | - | expression tag |
| Lys 1916 | - | expression tag |
| Asp 1917 | - | expression tag |
| Asp 1918 | - | expression tag |
| Asp 1919 | - | expression tag |
| Asp 1920 | - | expression tag |
| Lys 1921 | - | expression tag |
| His 1922 | - | expression tag |
| His 1923 | - | expression tag |
| His 1924 | - | expression tag |
| His 1925 | - | expression tag |
| His 1926 | - | expression tag |
| His 1927 | - | expression tag |
| His 1928 | - | expression tag |
| His 1929 | - | expression tag |
| His 1930 | - | expression tag |
| His 1931 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -25 | - | initiating methionine |
| Gly -24 | - | expression tag |
| Ser -23 | - | expression tag |
| Ser -22 | - | expression tag |
| His -21 | - | expression tag |
| His -20 | - | expression tag |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| Ser -15 | - | expression tag |
| Ser -14 | - | expression tag |
| Gly -13 | - | expression tag |
| Leu -12 | - | expression tag |
| Val -11 | - | expression tag |
| Pro -10 | - | expression tag |
| Arg -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Ser -7 | - | expression tag |
| His -6 | - | expression tag |
| Met -5 | - | expression tag |
| Glu -4 | - | expression tag |
| Asn -3 | - | expression tag |
| Leu -2 | - | expression tag |
| Tyr -1 | - | expression tag |
| Phe 0 | - | expression tag |
| Gln 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 270480.7 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 3685.2 | |
| Non-Polymers* | Number of molecules | 34 |
| Total formula weight | 16284.2 | |
| All* | Total formula weight | 290450.1 |
