9P6S
Cryo-EM structure of human integrin alpha5beta1 in complex with fibronectin (FN 7-10)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Integrin alpha-5 | polymer | 601 | 64733.8 | 1 | UniProt (P08648) | Homo sapiens (human) | CD49 antigen-like family member E,Fibronectin receptor subunit alpha,Integrin alpha-F,VLA-5 |
| 2 | B (B) | Integrin beta-1 | polymer | 440 | 48952.4 | 1 | UniProt (P05556) | Homo sapiens (human) | Fibronectin receptor subunit beta,Glycoprotein IIa,GPIIA,VLA-4 subunit beta |
| 3 | C (C) | Fibronectin | polymer | 183 | 19849.1 | 1 | UniProt (P02751) | Homo sapiens (human) | FN,Cold-insoluble globulin,CIG |
| 4 | D, G, J (D, G, J) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
| 5 | E (E) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
| 6 | F (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1114.0 | 1 | In PDB GlyTouCan (G64481DJ) | |||
| 7 | H, I (H, I) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 8 | K, L, M, N, S... (A, B) | MANGANESE (II) ION | non-polymer | 54.9 | 7 | Chemie (MN) PubChem (27854) | |||
| 9 | O, P, Q, R (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 10 | V, W, X (A, B, C) | water | water | 18.0 | 27 | Chemie (HOH) |
Sequence modifications
B: 6 - 445 (UniProt: P05556)
| PDB | External Database | Details |
|---|---|---|
| His 92 | Thr 112 | conflict |
| Thr 195 | Ser 215 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 133535.2 | |
| Branched | Number of molecules | 7 |
| Total formula weight | 4471.1 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1269.4 | |
| All* | Total formula weight | 139275.7 |
