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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9P6B

Cryo-EM structure of full-length human TRPV1 in the presence of alpha-humulene

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(A, B, C, D)		Transient receptor potential cation channel subfamily V member 1polymer1102124575.34UniProt (Q8NER1)
Pfam (PF12796)
Pfam (PF00023)
Pfam (PF00520)		Homo sapiens (human)TrpV1,Capsaicin receptor,Osm-9-like TRP channel 1,OTRPC1,Vanilloid receptor 1
2AA, BA, DA, E, EA...
(C, A, D, B)		(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphatenon-polymer760.132Chemie (POV)
3CA, F, MA, S
(C, A, D, B)		(2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoatenon-polymer867.14Chemie (8IJ)
4FA, I, PA, V
(C, A, D, B)		TRIDECANEnon-polymer184.44Chemie (TRD)
5O, TA
(A, D)		SODIUM IONnon-polymer23.02Chemie (NA)
6UA, VA, WA, XA
(A, B, C, D)		waterwater18.092Chemie (HOH)
Sequence modifications
A, B, C, D: 2 - 839 (UniProt: Q8NER1)
PDBExternal DatabaseDetails
Met -1-initiating methionine
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Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight498301.1
Non-Polymers*Number of molecules42
Total formula weight28574.4
All*Total formula weight526875.5
*Water molecules are not included.

245663

PDB entries from 2025-12-03

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