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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9P6B

Cryo-EM structure of full-length human TRPV1 in the presence of alpha-humulene

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000166molecular_functionnucleotide binding
A0004888molecular_functiontransmembrane signaling receptor activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
A0005245molecular_functionvoltage-gated calcium channel activity
A0005262molecular_functioncalcium channel activity
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005524molecular_functionATP binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0007166biological_processcell surface receptor signaling pathway
A0007635biological_processchemosensory behavior
A0015278molecular_functionintracellularly gated calcium channel activity
A0016020cellular_componentmembrane
A0019722biological_processcalcium-mediated signaling
A0032591cellular_componentdendritic spine membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0034605biological_processcellular response to heat
A0035091molecular_functionphosphatidylinositol binding
A0043005cellular_componentneuron projection
A0045211cellular_componentpostsynaptic membrane
A0046872molecular_functionmetal ion binding
A0050955biological_processthermoception
A0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
A0051219molecular_functionphosphoprotein binding
A0051289biological_processprotein homotetramerization
A0060079biological_processexcitatory postsynaptic potential
A0070588biological_processcalcium ion transmembrane transport
A0071312biological_processcellular response to alkaloid
A0071318biological_processcellular response to ATP
A0071468biological_processcellular response to acidic pH
A0097603molecular_functiontemperature-gated ion channel activity
A0098703biological_processcalcium ion import across plasma membrane
A0098982cellular_componentGABA-ergic synapse
A1901594biological_processresponse to capsazepine
A1902656biological_processcalcium ion import into cytosol
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000166molecular_functionnucleotide binding
B0004888molecular_functiontransmembrane signaling receptor activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
B0005245molecular_functionvoltage-gated calcium channel activity
B0005262molecular_functioncalcium channel activity
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005524molecular_functionATP binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0007166biological_processcell surface receptor signaling pathway
B0007635biological_processchemosensory behavior
B0015278molecular_functionintracellularly gated calcium channel activity
B0016020cellular_componentmembrane
B0019722biological_processcalcium-mediated signaling
B0032591cellular_componentdendritic spine membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0034605biological_processcellular response to heat
B0035091molecular_functionphosphatidylinositol binding
B0043005cellular_componentneuron projection
B0045211cellular_componentpostsynaptic membrane
B0046872molecular_functionmetal ion binding
B0050955biological_processthermoception
B0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
B0051219molecular_functionphosphoprotein binding
B0051289biological_processprotein homotetramerization
B0060079biological_processexcitatory postsynaptic potential
B0070588biological_processcalcium ion transmembrane transport
B0071312biological_processcellular response to alkaloid
B0071318biological_processcellular response to ATP
B0071468biological_processcellular response to acidic pH
B0097603molecular_functiontemperature-gated ion channel activity
B0098703biological_processcalcium ion import across plasma membrane
B0098982cellular_componentGABA-ergic synapse
B1901594biological_processresponse to capsazepine
B1902656biological_processcalcium ion import into cytosol
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000166molecular_functionnucleotide binding
C0004888molecular_functiontransmembrane signaling receptor activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
C0005245molecular_functionvoltage-gated calcium channel activity
C0005262molecular_functioncalcium channel activity
C0005515molecular_functionprotein binding
C0005516molecular_functioncalmodulin binding
C0005524molecular_functionATP binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0007166biological_processcell surface receptor signaling pathway
C0007635biological_processchemosensory behavior
C0015278molecular_functionintracellularly gated calcium channel activity
C0016020cellular_componentmembrane
C0019722biological_processcalcium-mediated signaling
C0032591cellular_componentdendritic spine membrane
C0034220biological_processmonoatomic ion transmembrane transport
C0034605biological_processcellular response to heat
C0035091molecular_functionphosphatidylinositol binding
C0043005cellular_componentneuron projection
C0045211cellular_componentpostsynaptic membrane
C0046872molecular_functionmetal ion binding
C0050955biological_processthermoception
C0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
C0051219molecular_functionphosphoprotein binding
C0051289biological_processprotein homotetramerization
C0060079biological_processexcitatory postsynaptic potential
C0070588biological_processcalcium ion transmembrane transport
C0071312biological_processcellular response to alkaloid
C0071318biological_processcellular response to ATP
C0071468biological_processcellular response to acidic pH
C0097603molecular_functiontemperature-gated ion channel activity
C0098703biological_processcalcium ion import across plasma membrane
C0098982cellular_componentGABA-ergic synapse
C1901594biological_processresponse to capsazepine
C1902656biological_processcalcium ion import into cytosol
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000166molecular_functionnucleotide binding
D0004888molecular_functiontransmembrane signaling receptor activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
D0005245molecular_functionvoltage-gated calcium channel activity
D0005262molecular_functioncalcium channel activity
D0005515molecular_functionprotein binding
D0005516molecular_functioncalmodulin binding
D0005524molecular_functionATP binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0007166biological_processcell surface receptor signaling pathway
D0007635biological_processchemosensory behavior
D0015278molecular_functionintracellularly gated calcium channel activity
D0016020cellular_componentmembrane
D0019722biological_processcalcium-mediated signaling
D0032591cellular_componentdendritic spine membrane
D0034220biological_processmonoatomic ion transmembrane transport
D0034605biological_processcellular response to heat
D0035091molecular_functionphosphatidylinositol binding
D0043005cellular_componentneuron projection
D0045211cellular_componentpostsynaptic membrane
D0046872molecular_functionmetal ion binding
D0050955biological_processthermoception
D0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
D0051219molecular_functionphosphoprotein binding
D0051289biological_processprotein homotetramerization
D0060079biological_processexcitatory postsynaptic potential
D0070588biological_processcalcium ion transmembrane transport
D0071312biological_processcellular response to alkaloid
D0071318biological_processcellular response to ATP
D0071468biological_processcellular response to acidic pH
D0097603molecular_functiontemperature-gated ion channel activity
D0098703biological_processcalcium ion import across plasma membrane
D0098982cellular_componentGABA-ergic synapse
D1901594biological_processresponse to capsazepine
D1902656biological_processcalcium ion import into cytosol
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"PubMed","id":"37117175","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GF8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GF9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GFA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues84
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"37117175","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GF8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GF9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GFA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues96
DetailsTransmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"37117175","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GF8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GF9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GFA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues56
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"37117175","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GF8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GF9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GFA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"37117175","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GF8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GF9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GFA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"37117175","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GF8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GF9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GFA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues152
DetailsTransmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"PubMed","id":"37117175","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GF8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GF9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GFA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues84
DetailsIntramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"37117175","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GF8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GF9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GFA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues104
DetailsTransmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"PubMed","id":"37117175","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GF8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GF9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GFA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues128
DetailsRepeat: {"description":"ANK 2","evidences":[{"source":"PubMed","id":"37117175","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GF8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GF9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GFA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues100
DetailsRepeat: {"description":"ANK 3","evidences":[{"source":"PubMed","id":"37117175","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GF8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GF9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GFA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues108
DetailsRepeat: {"description":"ANK 4","evidences":[{"source":"PubMed","id":"37117175","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GF8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GF9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GFA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues144
DetailsRepeat: {"description":"ANK 5","evidences":[{"source":"PubMed","id":"37117175","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GF8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GF9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GFA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues92
DetailsRepeat: {"description":"ANK 6","evidences":[{"source":"PubMed","id":"37117175","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GF8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GF9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GFA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues88
DetailsRepeat: {"description":"ANK 7","evidences":[{"source":"PubMed","id":"37117175","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GF8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GF9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GFA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues112
DetailsRegion: {"description":"AD","evidences":[{"source":"UniProtKB","id":"O35433","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues12
DetailsMotif: {"description":"Selectivity filter","evidences":[{"source":"UniProtKB","id":"O35433","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues44
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"O35433","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"37117175","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GF8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GF9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GFA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q9R186","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine; by PKA and PKD","evidences":[{"source":"UniProtKB","id":"O35433","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues8
DetailsModified residue: {"description":"Phosphothreonine; by PKA; in vitro","evidences":[{"source":"UniProtKB","id":"O35433","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine; by PKC/PRKCE","evidences":[{"source":"UniProtKB","id":"O35433","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"O35433","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O35433","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

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PDB entries from 2025-12-03

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