9P1M

Cryo-EM structure of CD73 in complex with antibody Sym024

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	5'-nucleotidase	polymer	536	59514.6	2	UniProt (P21589) Pfam (PF00149) Pfam (PF02872)	Homo sapiens (human)	5'-NT,5'-deoxynucleotidase,Ecto-5'-nucleotidase,IMP-specific 5'-nucleotidase,Thymidylate 5'-phosphatase
2	C, E (C, E)	Antibody Light Chain	polymer	214	23200.8	2		Homo sapiens (human)
3	D, F (D, F)	Antibody Heavy Chain	polymer	453	49603.7	2		Homo sapiens (human)
4	G, J (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
5	H, I, K, L (A, B)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)

Sequence modifications

A, B: 26 - 549 (UniProt: P21589)

PDB	External Database	Details
Leu 550	-	expression tag
Glu 551	-	expression tag
Gly 552	-	expression tag
Ser 553	-	expression tag
Gly 554	-	expression tag
Ser 555	-	expression tag
His 556	-	expression tag
His 557	-	expression tag
His 558	-	expression tag
His 559	-	expression tag
His 560	-	expression tag
His 561	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	264638.3
Non-Polymers*	Number of molecules	6
	Total formula weight	704.1
All*	Total formula weight	265342.3

*Water molecules are not included.