9P1M
Cryo-EM structure of CD73 in complex with antibody Sym024
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| C | TYR192-HIS198 | |
| D | TYR204-HIS210 | |
| D | PHE429-HIS435 |
| site_id | PS00785 |
| Number of Residues | 13 |
| Details | 5_NUCLEOTIDASE_1 5'-nucleotidase signature 1. LtILHTnDvHSrL |
| Chain | Residue | Details |
| A | LEU29-LEU41 |
| site_id | PS00786 |
| Number of Residues | 12 |
| Details | 5_NUCLEOTIDASE_2 5'-nucleotidase signature 2. YdamaLGNHEFD |
| Chain | Residue | Details |
| A | TYR110-ASP121 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22997138","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23142347","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34403084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4H1S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9N","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22997138","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23142347","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34403084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4H1S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H1Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9N","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22997138","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23142347","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34403084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4H1S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H1Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9N","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"34403084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7PBA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"23142347","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"23142347","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Lipidation: {"description":"GPI-anchor amidated serine","evidences":[{"source":"PubMed","id":"2129526","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22997138","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23142347","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
