9OVY

Cryo-EM structure of human PRMT5:MEP50 in complex with SAH and compounds 16-19F and HJL-1

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, D, F (A, G, E, C)	Protein arginine N-methyltransferase 5	polymer	637	72766.7	4	UniProt (O14744)	Homo sapiens (human)	72 kDa ICln-binding protein,Histone-arginine N-methyltransferase PRMT5,Jak-binding protein 1,Shk1 kinase-binding protein 1 homolog,SKB1Hs
2	B, E, G (B, F, D)	Methylosome protein 50	polymer	342	36757.2	3	UniProt (Q9BQA1)	Homo sapiens (human)	MEP-50,Androgen receptor cofactor p44,WD repeat-containing protein 77,p44/Mep50
3	H, K, N, Q (A, G, E, C)	4-({6-AMINO-5-BROMO-2-[(4-CYANOPHENYL)AMINO]PYRIMIDIN-4-YL}OXY)-3,5-DIMETHYLBENZONITRILE	non-polymer		435.3	4	Chemie (65B) PubChem (193962)
4	I, L, O, R (A, G, E, C)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	4	Chemie (SAH) PubChem (439155)
5	J, M, P, S (A, G, E, C)	8-chloro-1-[(2,4-diaminoquinazolin-7-yl)methyl]-3,4-dihydroquinolin-2(1H)-one	non-polymer		353.8	4	Chemie (A1CEU)

Contents of the asymmetric unit

Polymers	Number of chains	7
	Total formula weight	401338.4
Non-Polymers*	Number of molecules	12
	Total formula weight	4694.0
All*	Total formula weight	406032.4

*Water molecules are not included.