9OO6

Human PORCN bound to inhibitor C59

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Isoform 3 of Protein-serine O-palmitoleoyltransferase porcupine,Green fluorescent protein	polymer	725	81758.3	1	UniProt (Q9H237) UniProt (P42212) Pfam (PF03062) Pfam (PF01353)	Homo sapiens (human)	Protein MG61
2	B (A)	2-[4-(2-methylpyridin-4-yl)phenyl]-N-[4-(pyridin-3-yl)phenyl]acetamide	non-polymer		379.5	1	Chemie (A1CC5)
3	C (A)	Lauryl Maltose Neopentyl Glycol	non-polymer		1005.2	1	Chemie (AV0)
4	D (A)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
5	E (A)	water	water		18.0	10	Chemie (HOH)

Sequence modifications

A: 1 - 455 (UniProt: Q9H237)

PDB	External Database	Details
Ala 187	Cys 187	conflict
Ala 456	-	linker
Ala 457	-	linker
Ala 458	-	linker
Phe 459	-	linker
Glu 460	-	linker
Ser 461	-	linker
Arg 462	-	linker
Leu 463	-	linker
Glu 464	-	linker
Val 465	-	linker
Leu 466	-	linker
Phe 467	-	linker
Gln 468	-	linker
Gly 469	-	linker
Pro 470	-	linker
Ala 471	-	linker
Ala 472	-	linker
Ala 473	-	linker
Ala 474	-	linker
Val 475	-	linker

A: 476 - 712 (UniProt: P42212)

PDB	External Database	Details
Leu 538	Phe 64	conflict
Thr 539	Ser 65	conflict
Lys 680	Ala 206	conflict
Leu 705	His 231	conflict
Ser 713	-	expression tag
Gly 714	-	expression tag
Gly 715	-	expression tag
Ser 716	-	expression tag
Gly 717	-	expression tag
Trp 718	-	expression tag
Ser 719	-	expression tag
His 720	-	expression tag
Pro 721	-	expression tag
Gln 722	-	expression tag
Phe 723	-	expression tag
Glu 724	-	expression tag
Lys 725	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	81758.3
Non-Polymers*	Number of molecules	3
	Total formula weight	1450.1
All*	Total formula weight	83208.4

*Water molecules are not included.