9OMF
Cryo-EM structure of neddylated PCMTD1-ELOBC-CUL5-RBX2 (N8-CRL5-PCMTD1)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 | polymer | 358 | 40814.3 | 1 | UniProt (Q96MG8) Pfam (PF01135) | Homo sapiens (human) | |
| 2 | B (B) | Cullin-5 | polymer | 783 | 91436.7 | 1 | UniProt (Q93034) Pfam (PF00888) Pfam (PF10557) | Homo sapiens (human) | CUL-5,Vasopressin-activated calcium-mobilizing receptor 1,VACM-1 |
| 3 | C (C) | RING-box protein 2 | polymer | 113 | 12721.5 | 1 | UniProt (Q9WTZ1) Pfam (PF12678) | Mus musculus (Mouse) | Rbx2,RING finger protein 7,Sensitive to apoptosis gene protein |
| 4 | D (D) | Elongin-B | polymer | 118 | 13147.8 | 1 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 5 | E (E) | Elongin-C | polymer | 96 | 10843.4 | 1 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
Sequence modifications
A: 1 - 357 (UniProt: Q96MG8)
B: 1 - 780 (UniProt: Q93034)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| Ile 312 | Asn 312 | variant |
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Glu -1 | - | expression tag |
| Phe 0 | - | expression tag |
| Tyr 567 | Ser 567 | conflict |
| Val 619 | Leu 619 | conflict |
| Leu 767 | Arg 767 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 168963.7 | |
| All* | Total formula weight | 168963.7 |
