9OIO

The von Hippel Lindau-ElonginB-ElonginC (VCB) complex with fragments 9 and 14

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J (A, D, G, J)	Elongin-B	polymer	104	11748.4	4	UniProt (Q15370) Pfam (PF00240)	Homo sapiens (human)	EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
2	B, E, H, K (B, E, H, K)	Elongin-C	polymer	98	11031.7	4	UniProt (Q15369) Pfam (PF03931)	Homo sapiens (human)	EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1
3	C, F, L (C, F, L)	von Hippel-Lindau disease tumor suppressor	polymer	180	20833.5	3	UniProt (P40337) Pfam (PF01847) Pfam (PF17211)	Homo sapiens (human)	Protein G7,pVHL
4	I (I)	von Hippel-Lindau disease tumor suppressor	polymer	180	20729.5	1	UniProt (P40337) Pfam (PF01847) Pfam (PF17211)	Homo sapiens (human)	Protein G7,pVHL
5	M, P, W (C, F, L)	1-[(2-fluorophenyl)methyl]-4-(propan-2-yl)piperazine	non-polymer		236.3	3	Chemie (A1CBL)
6	N, Q, R, T, U... (C, F, H, I, L)	DIMETHYL SULFOXIDE	non-polymer		78.1	6	Chemie (DMS)
7	O, S, V (E, H, K)	1-[6-[oxidanyl(oxidanylidene)-$l^{4}-azanyl]-2,3-dihydroindol-1-yl]ethanone	non-polymer		206.2	3	Chemie (A1CBK)
8	AA, BA, CA, DA, EA... (C, D, E, F, G...)	water	water		18.0	250	Chemie (HOH)

Sequence modifications

B, E, H, K: 17 - 112 (UniProt: Q15369)

PDB	External Database	Details
Met 15	-	initiating methionine
Gly 16	-	expression tag

C, F, L: 54 - 213 (UniProt: P40337)

PDB	External Database	Details
Met 34	-	initiating methionine
Gly 35	-	expression tag
Ser 36	-	expression tag
Ser 37	-	expression tag
His 38	-	expression tag
His 39	-	expression tag
His 40	-	expression tag
His 41	-	expression tag
His 42	-	expression tag
His 43	-	expression tag
Ser 44	-	expression tag
Ser 45	-	expression tag
Gly 46	-	expression tag
Leu 47	-	expression tag
Val 48	-	expression tag
Pro 49	-	expression tag
Arg 50	-	expression tag
Gly 51	-	expression tag
Ser 52	-	expression tag
His 53	-	expression tag

I: 54 - 213 (UniProt: P40337)

PDB	External Database	Details
Met 34	-	expression tag
Gly 35	-	expression tag
Ser 36	-	expression tag
Ser 37	-	expression tag
His 38	-	expression tag
His 39	-	expression tag
His 40	-	expression tag
His 41	-	expression tag
His 42	-	expression tag
His 43	-	expression tag
Ser 44	-	expression tag
Ser 45	-	expression tag
Gly 46	-	expression tag
Leu 47	-	expression tag
Val 48	-	expression tag
Pro 49	-	expression tag
Arg 50	-	expression tag
Gly 51	-	expression tag
Ser 52	-	expression tag
His 53	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	174350.4
Non-Polymers*	Number of molecules	12
	Total formula weight	1796.4
All*	Total formula weight	176146.7

*Water molecules are not included.