9OH4
Cryo-EM structure of cGAS tetramer in complex with BuDNA (bubble DNA)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Cyclic GMP-AMP synthase | polymer | 357 | 41970.5 | 4 | UniProt (Q8C6L5) Pfam (PF03281) Pfam (PF20266) | Mus musculus (house mouse) | m-cGAS, 2'3'-cGAMP synthase, Mab-21 domain-containing protein 1 |
| 2 | E, G (E, G) | Bubble DNA Forward(41-MER) | polymer | 41 | 12694.2 | 2 | synthetic construct | ||
| 3 | F, H (F, H) | Bubble DNA Reverse(41-MER) | polymer | 41 | 12546.0 | 2 | synthetic construct | ||
| 4 | I, J, K, L (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) PubChem (32051) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 218362.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 261.6 | |
| All* | Total formula weight | 218624.2 |
