9OFU

Dimer of HIF-1a-ARNT Heterodimers Complexed on 52-bp HRE/HAS

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Hypoxia-inducible factor 1-alpha	polymer	373	42962.9	2	UniProt (Q16665) Pfam (PF23171) Pfam (PF00989) Pfam (PF08447)	Homo sapiens (human)	HIF-1-alpha,HIF1-alpha,ARNT-interacting protein,Basic-helix-loop-helix-PAS protein MOP1,Class E basic helix-loop-helix protein 78,bHLHe78,Member of PAS protein 1,PAS domain-containing protein 8
2	B, D (B, D)	Aryl hydrocarbon receptor nuclear translocator	polymer	381	43061.8	2	UniProt (P27540) Pfam (PF00010) Pfam (PF00989) Pfam (PF14598)	Homo sapiens (human)	ARNT protein,Class E basic helix-loop-helix protein 2,bHLHe2,Dioxin receptor,nuclear translocator,Hypoxia-inducible factor 1-beta,HIF-1-beta,HIF1-beta
3	E (E)	52-nt Hypoxia Response Element (Forward)	polymer	52	15821.1	1		Homo sapiens
4	F (F)	52-nt Hypoxia Response Element (Reverse)	polymer	52	16226.4	1		Homo sapiens

Sequence modifications

A, C: 3 - 361 (UniProt: Q16665)

PDB	External Database	Details
Met -11	-	initiating methionine
Gly -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Ser -1	-	expression tag
Gln 0	-	expression tag
Asp 1	-	expression tag
Pro 2	-	expression tag

B, D: 91 - 470 (UniProt: P27540)

PDB	External Database	Details
Met 90	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	204097.0
All*	Total formula weight	204097.0

*Water molecules are not included.