9OF2

Dimer of HIF-2a-ARNT Heterodimers Complexed on 51-bp HRE/HAS

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	51-nt Hypoxia Response Element (Forward)	polymer	51	15822.1	1	GenBank (182197)	Homo sapiens
2	B (B)	51-nt Hypoxia Response Element (Reverse)	polymer	51	15609.0	1	GenBank (182197)	Homo sapiens
3	C, E (C, E)	Endothelial PAS domain-containing protein 1	polymer	372	42684.5	2	UniProt (Q99814) Pfam (PF23171) Pfam (PF00989) Pfam (PF14598)	Homo sapiens (human)	EPAS-1,Basic-helix-loop-helix-PAS protein MOP2,Class E basic helix-loop-helix protein 73,bHLHe73,HIF-1-alpha-like factor,HLF,Hypoxia-inducible factor 2-alpha,HIF-2-alpha,HIF2-alpha,Member of PAS protein 2,PAS domain-containing protein 2
4	D, F (D, F)	Aryl hydrocarbon receptor nuclear translocator	polymer	381	43061.8	2	UniProt (P27540) Pfam (PF00010) Pfam (PF00989) Pfam (PF14598)	Homo sapiens (human)	ARNT protein,Class E basic helix-loop-helix protein 2,bHLHe2,Dioxin receptor,nuclear translocator,Hypoxia-inducible factor 1-beta,HIF-1-beta,HIF1-beta

Sequence modifications

C, E: 5 - 361 (UniProt: Q99814)

PDB	External Database	Details
Met -10	-	initiating methionine
Gly -9	-	expression tag
Ser -8	-	expression tag
Ser -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
Ser 0	-	expression tag
Gln 1	-	expression tag
Asp 2	-	expression tag
Pro 3	-	expression tag
Gly 4	-	expression tag

D, F: 91 - 470 (UniProt: P27540)

PDB	External Database	Details
Met 90	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	202923.6
All*	Total formula weight	202923.6

*Water molecules are not included.