9OF2

Dimer of HIF-2a-ARNT Heterodimers Complexed on 51-bp HRE/HAS

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0005634	cellular_component	nucleus
C	0005667	cellular_component	transcription regulator complex
C	0005737	cellular_component	cytoplasm
C	0006355	biological_process	regulation of DNA-templated transcription
C	0046983	molecular_function	protein dimerization activity
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0005634	cellular_component	nucleus
D	0005667	cellular_component	transcription regulator complex
D	0005737	cellular_component	cytoplasm
D	0006355	biological_process	regulation of DNA-templated transcription
D	0046983	molecular_function	protein dimerization activity
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0005634	cellular_component	nucleus
E	0005667	cellular_component	transcription regulator complex
E	0005737	cellular_component	cytoplasm
E	0006355	biological_process	regulation of DNA-templated transcription
E	0046983	molecular_function	protein dimerization activity
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0005634	cellular_component	nucleus
F	0005667	cellular_component	transcription regulator complex
F	0005737	cellular_component	cytoplasm
F	0006355	biological_process	regulation of DNA-templated transcription
F	0046983	molecular_function	protein dimerization activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	140
Details	Domain: {"description":"PAS 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00140","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	54
Details	Region: {"description":"DNA-binding","evidences":[{"source":"UniProtKB","id":"P97481","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	42
Details	Region: {"description":"Required for heterodimer formation with ARNT","evidences":[{"source":"UniProtKB","id":"P97481","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	43
Details	Domain: {"description":"PAC"}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	8
Details	Region: {"description":"Mediates the transcription activity and dimerization of the AHR:ARNT complex","evidences":[{"source":"UniProtKB","id":"P53762","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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