9OBN
Crystal structure of malaria transmission-blocking antigen Pfs48/45 C-terminal domain in complex with nanobody B2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Gametocyte surface protein P45/48 | polymer | 150 | 16682.5 | 4 | UniProt (Q8I6T1) Pfam (PF07422) | Plasmodium falciparum 3D7 | |
| 2 | E, F, G, H (E, H, G, F) | Nanobody B2 | polymer | 131 | 14140.7 | 4 | Vicugna pacos | ||
| 3 | I, J (D, E) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | K, L (E, F) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 2 | Chemie (EPE) | |||
| 5 | M, N, O, P, Q... (A, B, C, D, E...) | water | water | 18.0 | 383 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 291 - 428 (UniProt: Q8I6T1)
| PDB | External Database | Details |
|---|---|---|
| Glu 288 | - | expression tag |
| Thr 289 | - | expression tag |
| Gly 290 | - | expression tag |
| Tyr 308 | His 308 | engineered mutation |
| Leu 397 | Gly 397 | engineered mutation |
| Val 402 | Ile 402 | engineered mutation |
| Gly 429 | - | expression tag |
| Gly 430 | - | expression tag |
| Ser 431 | - | expression tag |
| Glu 432 | - | expression tag |
| Asn 433 | - | expression tag |
| Leu 434 | - | expression tag |
| Tyr 435 | - | expression tag |
| Phe 436 | - | expression tag |
| Gln 437 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 123292.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 668.7 | |
| All* | Total formula weight | 123961.6 |
