9O91

Structure of IKZF2:CRBN:Compound 5 ternary structure

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G (A, C, E, G)	Protein cereblon	polymer	111	12309.1	4	UniProt (Q96SW2) Pfam (PF03226)	Homo sapiens (human)
2	B, D, F, H (B, D, F, H)	Zinc finger protein Helios	polymer	30	3300.8	4	UniProt (Q9UKS7) Pfam (PF00096)	Homo sapiens (human)	Ikaros family zinc finger protein 2
3	I, L, O, R (A, C, E, G)	(3S)-3-[(5M)-1-oxo-5-{4-[(pyrrolidin-1-yl)methyl]-1H-pyrrolo[2,3-b]pyridin-6-yl}-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione	non-polymer		443.5	4	Chemie (A1CAC)
4	J, K, M, N, P... (A, B, C, D, E...)	ZINC ION	non-polymer		65.4	8	Chemie (ZN)
5	AA, BA, U, V, W... (G, H, A, B, C...)	water	water		18.0	285	Chemie (HOH)

Sequence modifications

A, C, E, G: 318 - 426 (UniProt: Q96SW2)

PDB	External Database	Details
Gly 316	-	expression tag
Pro 317	-	expression tag
Ser 318	Cys 318	engineered mutation
Ser 322	Cys 322	engineered mutation
Ser 343	Cys 343	engineered mutation
Ser 366	Cys 366	engineered mutation

B, D, F, H: 136 - 164 (UniProt: Q9UKS7)

PDB	External Database	Details
Gly 135	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	62439.3
Non-Polymers*	Number of molecules	12
	Total formula weight	2297.3
All*	Total formula weight	64736.5

*Water molecules are not included.