9O91

Structure of IKZF2:CRBN:Compound 5 ternary structure

This is a non-PDB format compatible entry.

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	PETRA III, DESY BEAMLINE P11
Synchrotron site	PETRA III, DESY
Beamline	P11
Temperature [K]	90
Detector technology	PIXEL
Collection date	2022-08-25
Detector	DECTRIS EIGER2 X 16M
Wavelength(s)	1.03321
Spacegroup name	P 1 21 1
Unit cell lengths	46.160, 70.180, 78.710
Unit cell angles	90.00, 90.01, 90.00

Refinement procedure

Resolution	46.200 - 1.860
R-factor	0.17734
Rwork	0.175
R-free	0.21758
Structure solution method	FOURIER SYNTHESIS
RMSD bond length	0.006
RMSD bond angle	1.531
Data reduction software	XDS
Data scaling software	Aimless
Phasing software	REFMAC
Refinement software	REFMAC (5.8.0430)

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	46.200	1.910
High resolution limit [Å]	1.860	1.870
Rmerge	0.300	0.910
Rmeas	0.325	1.002
Rpim	0.123	0.412
Total number of observations		13878
Number of reflections	41050	2493
<I/σ(I)>	8.9	3.1
Completeness [%]	98.7
Redundancy	6.8	5.6
CC(1/2)	0.992	0.839

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION, HANGING DROP		291.15	0.2 M Magnesium chloride 0.1 M TRIS pH 8.5 33 % w/v PEG 4000